Killer ILCs in the Fat Immunity

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Presentation transcript:

Killer ILCs in the Fat Immunity Emilie Narni-Mancinelli, Eric Vivier Immunity Volume 46, Issue 2, Pages 169-171 (February 2017) DOI: 10.1016/j.immuni.2017.02.004 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 AT1-ILC Subsets in Mice and Humans The heterogeneity of mouse and human AT type 1 ILCs is schematized with major phenotypic markers and transcription factors. Mouse AT1-ILCs can be subdivided in several subsets based on the expression of CD49b and CD49a integrins. iNK and mNK cells share common features with splenic NK cells whereas mixed ILC1s resemble liver ILC1s. Phenotype of splenic NK cells and liver ILC1s are indicated for comparison. Features of the human AT1 ILCs are shown with the enrichment in CD56dimCD16− ILCs as compared to peripheral blood NK cells. Abbreviations are as follows: AT1-ILCs, adipose tissue type 1 ILCs; iNK, immature NK cells; mNK, mature NK cells; dep, dependent; indep, independent; Eomes, eomesodermin; GZMB, granzyme b; PZF, perforin; IFN-γ, interferon gamma; Mφ, macrophage. Immunity 2017 46, 169-171DOI: (10.1016/j.immuni.2017.02.004) Copyright © 2017 Elsevier Inc. Terms and Conditions