Genetic Linkage of Hyper-IgE Syndrome to Chromosome 4

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Genetic Linkage of Hyper-IgE Syndrome to Chromosome 4 Bodo Grimbacher, Alejandro A. Schäffer, Steven M. Holland, Joie Davis, John I. Gallin, Harry L. Malech, T. Prescott Atkinson, Bernd H. Belohradsky, Rebecca H. Buckley, Fausto Cossu, Teresa Español, Ben-Zion Garty, Nuria Matamoros, Laurie A. Myers, Robert P. Nelson, Hans D. Ochs, Eleonore D. Renner, Nele Wellinghausen, Jennifer M. Puck The American Journal of Human Genetics Volume 65, Issue 3, Pages 735-744 (September 1999) DOI: 10.1086/302547 Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 1 Pedigrees of multiplex HIES families. Numbers adjacent to pedigree symbols indicate HIES score (see table 2). Blackened symbols indicate a score of ⩾15 (classification of “affected”); striped symbols indicate a score of 10–14 (classification of “unknown”); unblackened symbols indicate a score of 0–9 (classification of “unaffected”); and a slash indicates a deceased family member. The American Journal of Human Genetics 1999 65, 735-744DOI: (10.1086/302547) Copyright © 1999 The American Society of Human Genetics Terms and Conditions

Figure 2 Four-point linkage analysis of HIES. LOD scores were calculated at the points shown, and linear interpolation was used in between. The American Journal of Human Genetics 1999 65, 735-744DOI: (10.1086/302547) Copyright © 1999 The American Society of Human Genetics Terms and Conditions