Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy T.E.

Slides:

Advertisements

Similar presentations

2015 Alzheimer's disease facts and figures Alzheimer's & Dementia: The Journal of the Alzheimer's Association Volume 11, Issue 3, Pages (March.

Advertisements

Effects of intraoperative and early postoperative normal saline or Plasma-Lyte 148® on hyperkalaemia in deceased donor renal transplantation: a double-blind.

Human factors in anaesthesia: lessons from aviation

Four phases of intravenous fluid therapy: a conceptual model†

Change in end-tidal carbon dioxide outperforms other surrogates for change in cardiac output during fluid challenge K Lakhal, M.A. Nay, T Kamel, B Lortat-Jacob,

Adverse event reporting tool to standardize the reporting and tracking of adverse events during procedural sedation: a consensus document from the World.

C. Dubost, A. Le Gouez, P. J. Zetlaoui, D. Benhamou, F. J. Mercier, T

Validation of volume kinetic analysis of glucose 2

Predictive performance of eleven pharmacokinetic models for propofol infusion in children for long-duration anaesthesia M Hara, K Masui, D.J. Eleveld,

Reduction in mortality after epidural anaesthesia and analgesia in patients undergoing rectal but not colonic cancer surgery: a retrospective analysis.

C.-A. Ewaldsson, R.G. Hahn British Journal of Anaesthesia

A.C. Krediet, C.J. Kalkman, M.J. Bonten, A.C.M. Gigengack, P. Barach

Choice of fluid in acute illness: what should be given

Parkinson's disease and anaesthesia

Comparison of positive end-expiratory pressure–induced increase in central venous pressure and passive leg raising to predict fluid responsiveness in.

M. Zaar, B. Lauritzen, N. H. Secher, T. Krantz, H. B. Nielsen, P. L

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery:

Pharmacokinetics of ropivacaine in patients with chronic renal failure

A different use of visual analytic techniques in anaesthetics

Routine use of viscoelastic blood tests for diagnosis and treatment of coagulopathic bleeding in cardiac surgery: updated systematic review and meta-analysis

S.J. Howell, J.J. Pandit, D.J. Rowbotham

Secondary spread of caudal block as assessed by ultrasonography

A rational approach to fluid therapy in sepsis

Efficacy of intravenous magnesium in neuropathic pain

The significant contribution of the partitioning effect in lipid resuscitation for bupivacaine- induced cardiotoxicity: evaluation using centrifuged solution.

Anaesthetists’ non-technical skills

C. Boer, S.M. Bossers, N.J. Koning British Journal of Anaesthesia

Changes in serum albumin concentration and volume expanding effects following a bolus of albumin 20% in septic patients Margarson M.P. , Soni N.C.

Isotonic crystalloid solutions: a structured review of the literature

Anaemia during critical illness

The novel Kv1.5 channel blocker vernakalant for successful treatment of new-onset atrial fibrillation in a critically ill abdominal surgical patient

Magnesium sulphate as a technique of hypotensive anaesthesia

Physiological effects of hyperchloraemia and acidosis

Volume kinetics of glucose solutions given by intravenous infusion†

Spinal anaesthesia: a comparison of plain ropivacaine 5 mg ml−1 with bupivacaine 5 mg ml−1 for major orthopaedic surgery T.M. Cook, D.A. McNamee, K.R.

S.G. Sakka, K. Reinhart, A. Meier-Hellmann

Delta down compared with delta pulse pressure as an indicator of volaemia during intracranial surgery E. Deflandre, V. Bonhomme, P. Hans British Journal.

Interstitial muscle concentrations of rocuronium under steady-state conditions in anaesthetized dogs: actual versus predicted values Ezzine S. , Varin.

Predictive value of pulse pressure variation for fluid responsiveness in septic patients using lung-protective ventilation strategies F.G.R. Freitas,

Acute traumatic coagulopathy: pathophysiology and resuscitation

C. J. Payne, S. C. Gibson, G. Bryce, A. G. Jardine, C. Berry, D. B

Rapid sequence induction and intubation with rocuronium–sugammadex compared with succinylcholine: a randomized trial M.K. Sørensen, C. Bretlau, M.R.

Single-dose intravenous paracetamol or propacetamol for prevention or treatment of postoperative pain: a systematic review and meta-analysis E.D. McNicol,

Multicentre cohort study of red blood cell use for revision hip arthroplasty and factors associated with greater risk of allogeneic blood transfusion

R. Onia, Y. Wu, V. Parvu, I. Eshun-Wilson, K. Kassler-Taub

Perioperative goal-directed therapy with uncalibrated pulse contour methods: impact on fluid management and postoperative outcome F. Michard, M.T. Giglio,

J.-L. Vincent, M.M. Wilkes, R.J. Navickis

Teamwork, communication, and anaesthetic assistance in Scotland

Effects of acute plasma volume expansion on renal perfusion, filtration, and oxygenation after cardiac surgery: a randomized study on crystalloid vs colloid

Neurological biomarkers in the perioperative period

Validity of the 6 min walk test in prediction of the anaerobic threshold before major non- cardiac surgery R.C.F. Sinclair, A.M. Batterham, S. Davies,

Does hyperbaric oxygen have positive effect on neurological recovery in spinal–epidural haematoma?: a case report Z. Wajima, S. Aida British Journal.

Human cerebral microcirculation and oxygen saturation during propofol-induced reduction of bispectral index† K.U. Klein, K. Fukui, P. Schramm, A. Stadie,

Meningitis or epidural abscesses after neuraxial block for removal of infected hip or knee prostheses K. Gritsenko, D. Marcello, G.A. Liguori, K. Jules-Elyse'e,

Influence of the site of measurement on the ability of plethysmographic variability index to predict fluid responsiveness F.-P. Desgranges, O. Desebbe,

Thrombocytopenia and acute Budd–Chiari syndrome after liver transplantation: heparin- induced thrombocytopenia S. Roullet, M. Biais, L. Stecken, C. Laurent,

ICU fire evacuation preparedness in London: a cross-sectional study

Suspected opioid-induced hyperalgesia in an infant

G. Haller, D.S. Courvoisier, H. Anderson, P.S. Myles

Discriminant analysis for anaesthetic decision-making: an intelligent recognition system for epidural needle insertion S.P. Lin, M.S. Mandell, Y. Chang,

J. Carlisle, M. Swart, E.J.C. Dawe, M. Chadwick

T. Tatara, T. Tsunetoh, C. Tashiro British Journal of Anaesthesia

International practices of organ donation

Remifentanil patient-controlled analgesia effect-site target-controlled infusion compared with morphine patient-controlled analgesia for treatment of.

Predictor of fluid responsiveness in the ‘grey zone’: augmented pulse pressure variation through a temporary increase in tidal volume J.J. Min, N.-S.

D.A. Rowney, R. Fairgrieve, B. Bissonnette

C.M. Chalmers, A.M. Bal British Journal of Anaesthesia

Effectiveness of electroacupuncture analgesia compared with opioid administration in a dog model: a pilot study D. Groppetti, A.M. Pecile, P. Sacerdote,

Plasma lidocaine concentrations following insertion of 2% lidocaine gel into the uterine cavity after uterine balloon thermal ablation G.F. Rousseau,

R. Parke, S. McGuinness, R. Dixon, A. Jull

Presentation transcript:

Revised Starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy T.E. Woodcock, T.M. Woodcock British Journal of Anaesthesia Volume 108, Issue 3, Pages 384-394 (March 2012) DOI: 10.1093/bja/aer515 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 A cartoon illustrating that the intravascular volume contains the non-circulating glycocalyx fluid volume and the circulating plasma volume. Red blood cells are excluded from the glycocalyx layer. Compaction of the glycocalyx layer increases plasma volume and the red cell dilution volume independently of changes in intravascular volume. British Journal of Anaesthesia 2012 108, 384-394DOI: (10.1093/bja/aer515) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 A cartoon illustrating some anatomic differences between four capillary phenotypes. British Journal of Anaesthesia 2012 108, 384-394DOI: (10.1093/bja/aer515) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 Autotransfusion. Transendothelial filtration rate Jv is proportional to the capillary pressure, or transendothelial pressure difference if interstitial pressure is not constant. Normal capillary pressure is nominally 20 mm Hg, and the scale for Jv is arbitrary, although studies show the rate of clearance from the intravascular space during rapid infusion of Ringer's acetate in humans can be as much as 100 ml min−1. Raising the plasma COP slows filtration (pink line), while reducing plasma COP increases it (green line). British Journal of Anaesthesia 2012 108, 384-394DOI: (10.1093/bja/aer515) Copyright © 2012 The Author(s) Terms and Conditions

Fig 4 The no absorption rule. With less acute reduction in capillary pressure, the glycocalyx model preserves filtration at a very low rate without a phase of absorption, the no absorption rule. We call the inflection on the filtration curve the J point. British Journal of Anaesthesia 2012 108, 384-394DOI: (10.1093/bja/aer515) Copyright © 2012 The Author(s) Terms and Conditions