Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic.

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Undifferentiated human mesenchymal stem cells (hMSCs) are highly sensitive to mechanical strain: transcriptionally controlled early osteo-chondrogenic response in vitro G. Friedl, M.D., H. Schmidt, M.D., Ph.D., I. Rehak, Ph.D., G. Kostner, Ph.D., M.D., K. Schauenstein, Ph.D., M.D., R. Windhager, M.D. Osteoarthritis and Cartilage Volume 15, Issue 11, Pages 1293-1300 (November 2007) DOI: 10.1016/j.joca.2007.04.002 Copyright © 2007 Terms and Conditions

Fig. 1 Relative gene expression levels of unstrained hMSCs (Co). Each symbol represents one of 10 sex- and age-matched donors. The figure demonstrates transcriptional heterogeneity and pronounced donor-to-donor variance in hMSCs. Osteoarthritis and Cartilage 2007 15, 1293-1300DOI: (10.1016/j.joca.2007.04.002) Copyright © 2007 Terms and Conditions

Fig. 2 Response of hMSCs to CTS. All mRNA expression levels of the chondrogenic and osteogenic marker genes were significantly up-regulated in the response to CTS (P<0.05), with the exception of FOS (P=0.105). Osteoarthritis and Cartilage 2007 15, 1293-1300DOI: (10.1016/j.joca.2007.04.002) Copyright © 2007 Terms and Conditions