MODIFIED POSTPARTUM MAGNESIUM SULPHATE REGIMEN IN SEVERE PRE-ECLAMPSIA Dr.Aung Khin Sint  

Background Pre-eclampsia occurs in 5- 8% of pregnancies. An important complication is progression to eclampsia. Eclampsia is defined as the presence of new-onset grandmal seizures in a woman with pre-eclampsia. Eclampsia remains an important cause of maternal and fetal morbidity and mortality. Use of magnesium sulphate in patients with severe pre- eclampsia reduces the risk of progression to eclampsia by more than half and reduced maternal mortality.

Objective To study the effects of modified postpartum magnesium sulphate regimen in severe pre-eclampsia in Central Women’s Hospital, Mandalay  

Method This hospital based randomized comparative study was done at Central Women Hospital, Mandalay from 1st Junarary, 2015 to December, 2015 to study the effects of modified postpartum magnesium sulphate regimen in severe pre-eclampsia. Total 108 patients were involved in this study. Patients were equally allocated by the sequence of computer generated balanced randomization block which placed in numbered sealed envelopes with packages.

In modified regimen, postpartum magnesium sulphate prophylaxis was given for 12 hours postpartum. In standard regimen, postpartum magnesium sulphate prophylaxis was given for 24 hours postpartum.

Results 12 hours group 24 hours group P-value Success rate for prevention of eclamptic fits 100% Magnesium sulphate toxicity 0% 1.9% P =1.000 Continuation of MgSO4 therapy 3.7% P=0.495 Reinitiation of MgSO4 therapy P=1.000

 Conclusion The sample size for this study was 108 patients and the results were not statistically significant.