Volume 19, Issue 1, Pages (January 2014)

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Volume 19, Issue 1, Pages 146-154 (January 2014) Analysis of Transcription Factors Key for Mouse Pancreatic Development Establishes NKX2-2 and MNX1 Mutations as Causes of Neonatal Diabetes in Man Sarah E. Flanagan, Elisa De Franco, Hana Lango Allen, Michele Zerah, Majedah M. Abdul-Rasoul, Julie A. Edge, Helen Stewart, Elham Alamiri, Khalid Hussain, Sam Wallis, Liat de Vries, Oscar Rubio-Cabezas, Jayne A.L. Houghton, Emma L. Edghill, Ann-Marie Patch, Sian Ellard, Andrew T. Hattersley Cell Metabolism Volume 19, Issue 1, Pages 146-154 (January 2014) DOI: 10.1016/j.cmet.2013.11.021 Copyright © 2014 The Authors Terms and Conditions

Cell Metabolism 2014 19, 146-154DOI: (10.1016/j.cmet.2013.11.021) Copyright © 2014 The Authors Terms and Conditions

Figure 1 NKX2-2 and MNX1 Mutations in Four Families with Neonatal Diabetes (A) Partial pedigrees of two families in which NKX2-2 mutations were identified. Below each pedigree is an electropherogram depicting the homozygous mutation identified in each proband. N/A, not available. (B) Partial pedigrees of two families with MNX1 mutations. Below each pedigree is an electropherogram depicting the homozygous mutation identified in each proband. (C) The highly conserved sequence of the homeobox domain within MNX1 is provided for various species. An arrow points to the residues found to be mutated in the two probands with permanent neonatal diabetes. See also Figure S1. Cell Metabolism 2014 19, 146-154DOI: (10.1016/j.cmet.2013.11.021) Copyright © 2014 The Authors Terms and Conditions