C. P. Baur, W. Klingler, K. Jurkat-Rott, G. Froeba, E. Schoch, T

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Xenon does not induce contracture in human malignant hyperthermia muscle† C.P. Baur, W. Klingler, K. Jurkat-Rott, G. Froeba, E. Schoch, T. Marx, M. Georgieff, F. Lehmann-Horn British Journal of Anaesthesia Volume 85, Issue 5, Pages 712-716 (November 2000) DOI: 10.1093/bja/85.5.712 Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 1 IVCT trace of a MHN (a) and MHS (b) muscle specimen during exposure to halothane (0.5–4.0%). MHS specimens showed a marked increase in baseline tension and twitch force. The vertical lines indicate the application of the halothane concentration specified on top of the graph (in %). IVCT trace of a MHN (c) and MHS (d) muscle specimen during exposure to caffeine (0.5–32 mM) MHS specimens showed a marked increase in baseline tension and twitch force. The vertical lines indicate the application of the caffeine concentration specified on top of the graph (in mM). British Journal of Anaesthesia 2000 85, 712-716DOI: (10.1093/bja/85.5.712) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 2 Dose-response curves of the twitch force due to exposure to caffeine (a) and halothane (b). Twitch force increase is given in percent relative to the predrug value. Error bars indicate sem. Values that are significantly different are marked by an asterisk (*). British Journal of Anaesthesia 2000 85, 712-716DOI: (10.1093/bja/85.5.712) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions

Fig 3 IVCT trace of a MHN (a) and MHS (b) muscle specimen during exposure to xenon (70%). No increase in baseline tension, but a slight increase in twitch force is notable. The vertical line indicates the start of the application of 70% xenon. IVCT trace of a MHS (c) muscle specimen during successive exposure to xenon (70%) and subsequently to halothane (3%). A marked increase in baseline tension is visible only after halothane exposure. The first vertical line indicates the start of the application of 70% xenon, the second indicates discontinuation of xenon and simultaneous start of 3% halothane exposure. British Journal of Anaesthesia 2000 85, 712-716DOI: (10.1093/bja/85.5.712) Copyright © 2000 British Journal of Anaesthesia Terms and Conditions