Intra-articular supplementation with recombinant human GDF5 arrests disease progression and stimulates cartilage regeneration in the rat medial meniscus.

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Intra-articular supplementation with recombinant human GDF5 arrests disease progression and stimulates cartilage regeneration in the rat medial meniscus transection (MMT) model of osteoarthritis B.A. Byers, W.R. Parrish, J. Geesin, U. Herzberg, S. Wadsworth, A.M. Bendele, B.J. Story Osteoarthritis and Cartilage Volume 22, Pages S471-S472 (April 2014) DOI: 10.1016/j.joca.2014.02.897 Copyright © 2014 Terms and Conditions

Figure 1) Representative micrographs of the medial tibial plateau (bottom) and medial femoral condyle (top) from study # 3. 50X original magnification Osteoarthritis and Cartilage 2014 22, S471-S472DOI: (10.1016/j.joca.2014.02.897) Copyright © 2014 Terms and Conditions

Figure 2) Quantitation of the effects of rhGDF5 intra-articular therapy on significant cartilage lesion width of the medial tibial plateau. Day 21 untreated group indicates the extent of cartilage erosion present at the onset of therapy. Data represent 15 rats/group from study # 3. Osteoarthritis and Cartilage 2014 22, S471-S472DOI: (10.1016/j.joca.2014.02.897) Copyright © 2014 Terms and Conditions