Fig. 7. NPs accumulate at sites of vascular obstruction.

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Volume 93, Issue 3, Pages (March 2018)

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Fig. 7. NPs accumulate at sites of vascular obstruction. NPs accumulate at sites of vascular obstruction. (A) Three-dimensional projection of a z-stack of confocal images of a vessel containing a high density of nonspecific NP accumulation in its lumen (DAPI, blue; CD31-NPs, red; Control-NPs, green; NP overlay, yellow; Ulex, white). Dashed white line represents the point of apparent obstruction, and arrows highlight apparent red blood cells (RBCs). Scale bar, 10 μm. (B) Representative image of nonspecific colocalization of NPs with sites of high-density RBC (glycophorin A, white; nonspecific NP, yellow) presumably representing vascular obstruction. Scale bar, 10 μm. (C) Quantification of relative NP signal (CD31-NP/Control-NP) for image in (B). (D) Representative hematoxylin and eosin–stained images of kidney 5 (100 μg/ml) before NP introduction (pre-NP) or after 4 hours of NP perfusion. RBC occlusions are stained red. Scale bars, 100 μm. Gregory T. Tietjen et al., Sci Transl Med 2017;9:eaam6764 Published by AAAS