Personalized Medicine in Psychiatry Cognitive gene risk profile for the prediction of cognitive decline in presymptomatic Alzheimer’s disease  Tenielle Porter, Victor L. Villemagne, Greg Savage, Lidija Milicic, Yen Ying Lim, Paul Maruff, Colin L. Masters, David Ames, Ashley I. Bush, Ralph N. Martins, Stephanie Rainey-Smith, Christopher C. Rowe, Kevin Taddei, David Groth, Giuseppe Verdile, Samantha C. Burnham, Simon M. Laws  Personalized Medicine in Psychiatry   Volume 7, Pages 14-20 (March 2018) DOI: 10.1016/j.pmip.2018.03.001 Copyright © 2018 Elsevier Inc. Terms and Conditions

Fig. 1 Cognitive Gene Risk Profile (Cog-GRP). (a) Derivation of the Cognitive Gene Risk Profile (Cog-GRP) within cognitively normal adults high Aβ-amyloid (Aβhigh; n = 127) using decision tree analysis. Defining four groups ε4+ Risk (red, n = 40), ε4+ Resilient (orange, n = 26), ε4− Risk (blue, n = 43), ε4− Resilient (green, n = 18). Values represent SD/year change in the verbal episodic memory composite. All analyses were corrected for age, sex, years of education, premorbid IQ and depressive symptoms. (b) Confirmation of performance of collapsed groups identified by the Cog-GRP in Aβhigh cognitively normal adults (n = 127) and comparative performance of APOE when considered independently. ε4− Resilient group (green line), ε4− Risk group (blue line), ε4+ Resilient group (orange line), ε4+ Risk group (red line), APOE ε4−ve (grey dotted line), APOE ε4+ve (black dotted line). Broken black line represents 1.5 SD of decline. Error bars represent time dependent standard error, *p < 0.05 when comparing to the ε4+ Risk group. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Personalized Medicine in Psychiatry  2018 7, 14-20DOI: (10.1016/j.pmip.2018.03.001) Copyright © 2018 Elsevier Inc. Terms and Conditions

Fig. 2 Cognitive rates of change in Aβhigh CN older adults. Cognitive rates of change are presented for a (a) global composite, (b) clinical progression composite, and (c) Pre-Alzheimer’s Cognitive Composite (AIBL-PACC) in cognitively normal (CN) older adults with high Aβ-amyloid (Aβhigh; n = 127). ε4− Resilient group (green line), ε4− Risk group (blue line), ε4+ Resilient group (orange line), ε4+ Risk group (red). AIBL-PACC controlled for age. Error bars represent time dependent standard error, *p < 0.05 when comparing to the ε4+ Risk group. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.) Personalized Medicine in Psychiatry  2018 7, 14-20DOI: (10.1016/j.pmip.2018.03.001) Copyright © 2018 Elsevier Inc. Terms and Conditions