Volume 73, Issue 4, Pages (February 2008)

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Presentation transcript:

Volume 73, Issue 4, Pages 375-376 (February 2008) Unraveling the role of connective tissue growth factor in diabetic nephropathy K.M. Schmidt-Ott Kidney International Volume 73, Issue 4, Pages 375-376 (February 2008) DOI: 10.1038/sj.ki.5002661 Copyright © 2008 International Society of Nephrology Terms and Conditions

Figure 1 Local modulation of signaling activity by CTGF. CTGF modulates the WNT, bone morphogenetic protein (BMP), and transforming growth factor-β (TGFβ) pathways but also signals directly via known and putative receptors, thereby potentiating harmful and inhibiting protective signals. Although the indicated interactions have been demonstrated in various biological systems, their individual roles in diabetic nephropathy remain to be determined. FZD, frizzled receptor; ITG, integrin-type receptors. Kidney International 2008 73, 375-376DOI: (10.1038/sj.ki.5002661) Copyright © 2008 International Society of Nephrology Terms and Conditions