Control lymphocyte subsets: Can one country's values serve for another's? Wilson L. Mandala, PhD, Jintanat Ananworanich, MD, PhD, Tanakorn Apornpong,

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Control lymphocyte subsets: Can one country's values serve for another's? Wilson L. Mandala, PhD, Jintanat Ananworanich, MD, PhD, Tanakorn Apornpong, MSc, Stephen J. Kerr, PhD, Jenny M. MacLennan, MRCP, MRCPCH, Celine Hanson, MD, Tanyathip Jaimulwong, MSc, Esther N. Gondwe, PhD, Howard M. Rosenblatt, MD, Torsak Bunupuradah, MD, Malcolm E. Molyneux, FMedSci, Stephen A. Spector, MD, Chitsanu Pancharoen, MD, Rebecca S. Gelman, PhD, Calman A. MacLennan, DPhil, FRCP, FRCPath, William T. Shearer, MD, PhD Journal of Allergy and Clinical Immunology Volume 134, Issue 3, Pages 759-761.e8 (September 2014) DOI: 10.1016/j.jaci.2014.06.030 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Box plots of total T-cell (A), CD4+ T-cell (B), CD8+ T-cell (C), and total B-cell counts (D) (box, 25th-75th percentiles; line, median; whiskers, lowest and highest points within 1.5 × the interquartile range) in children by country cohort and age group. Pairwise comparisons between lymphocyte subset distributions of children from each country were made in each age group by using a Mann-Whitney-Wilcoxon test, and P values of less than .05 were considered significant. *Significant difference in the Malawian or Thai (depending on the bar below the symbol) versus the US cohort. #Significant difference from the Malawian cohort versus the Thai cohort. M, Malawian cohort; TH, Thai cohort; U, US cohort. Journal of Allergy and Clinical Immunology 2014 134, 759-761.e8DOI: (10.1016/j.jaci.2014.06.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Box plots of total T-cell (A), CD4+ T-cell (B), CD8+ T-cell (C), and total B-cell (D) percentages in children by country cohort and age group. Pairwise comparisons between lymphocyte subset distributions of children from each country were made in each age group by using a Mann-Whitney-Wilcoxon test, and P values of less than .05 were considered significant. *Significant difference in the Malawian or Thai versus (depending on the bar below the symbol) the US cohort. #Significant difference from the Malawian cohort versus the Thai cohort. M, Malawian cohort; TH, Thai cohort; U, US cohort. Journal of Allergy and Clinical Immunology 2014 134, 759-761.e8DOI: (10.1016/j.jaci.2014.06.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Box plots of NK cell counts and percentages in children by country cohort and age group. Statistical analysis was done as for Fig E1. M, Malawian cohort; TH, Thai cohort; U, US cohort. Journal of Allergy and Clinical Immunology 2014 134, 759-761.e8DOI: (10.1016/j.jaci.2014.06.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 CD4/CD8 cell ratios in children by country cohort and age group. Statistical analysis was done as for Fig E1. M, Malawian cohort; TH, Thai cohort; U, US cohort. Journal of Allergy and Clinical Immunology 2014 134, 759-761.e8DOI: (10.1016/j.jaci.2014.06.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Proportion of healthy children from each country meeting World Health Organization 2006 treatment guideline case definitions for immune deficiency: age 11 months or less, CD4 <35%; age 12 to 35 months, CD4 <30%; age 36 to 59 months, CD4 <25%; and age 5 years or greater, CD4 <500 cells/mm3. *P < .05 for the age group by using a χ2 test. Journal of Allergy and Clinical Immunology 2014 134, 759-761.e8DOI: (10.1016/j.jaci.2014.06.030) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions