GFR Decline and Subsequent Risk of Established Kidney Outcomes: A Meta-analysis of 37 Randomized Controlled Trials Hiddo J. Lambers Heerspink, PhD, Hocine.

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Presentation transcript:

GFR Decline and Subsequent Risk of Established Kidney Outcomes: A Meta-analysis of 37 Randomized Controlled Trials Hiddo J. Lambers Heerspink, PhD, Hocine Tighiouart, MS, Yingying Sang, MSc, Shoshana Ballew, PhD, Hasi Mondal, MPH, Kunihiro Matsushita, MD, PhD, Josef Coresh, MD, PhD, Andrew S. Levey, MD, Lesley A. Inker, MD, MS American Journal of Kidney Diseases Volume 64, Issue 6, Pages 860-866 (December 2014) DOI: 10.1053/j.ajkd.2014.08.018 Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Adjusted hazard of the composite established kidney end point associated with percent change in estimated glomerular filtration rate (eGFR) during a 1-year baseline period. Hazard ratios for 30%, 40%, and 57% decline in eGFR are shown in the graph. The histogram in the bottom of the graph shows the distribution of percent change in eGFR. American Journal of Kidney Diseases 2014 64, 860-866DOI: (10.1053/j.ajkd.2014.08.018) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Metaregression of (left graphs) 30% and (right graphs) 40% estimated glomerular filtration rate (eGFR) declines with established kidney end point. Abbreviations: BP, blood pressure; CKD UC, chronic kidney disease unspecified cause; HTN, hypertension; IgA, immunoglobulin A; IS, immunosuppression; RAS1, renin-angiotensin-system blockers versus placebo; RAS2; renin-angiotensin system blockers versus calcium antagonists. Labels refer to study numbers in Table S1. American Journal of Kidney Diseases 2014 64, 860-866DOI: (10.1053/j.ajkd.2014.08.018) Copyright © 2014 National Kidney Foundation, Inc. Terms and Conditions