Volume 70, Issue 1, Pages 133-141 (January 2019) Longitudinal correlations between MRE, MRI-PDFF, and liver histology in patients with non-alcoholic steatohepatitis: Analysis of data from a phase II trial of selonsertib  Saumya Jayakumar, Michael S. Middleton, Eric J. Lawitz, Parvez S. Mantry, Stephen H. Caldwell, Hays Arnold, Anna Mae Diehl, Reem Ghalib, Magdy Elkhashab, Manal F. Abdelmalek, Kris V. Kowdley, C. Stephen Djedjos, Ren Xu, Ling Han, G. Mani Subramanian, Robert P. Myers, Zachary D. Goodman, Nezam H. Afdhal, Michael R. Charlton, Claude B. Sirlin, Rohit Loomba  Journal of Hepatology  Volume 70, Issue 1, Pages 133-141 (January 2019) DOI: 10.1016/j.jhep.2018.09.024 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Journal of Hepatology 2019 70, 133-141DOI: (10. 1016/j. jhep. 2018. 09 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Association between liver stiffness by MRE and fibrosis stage. (A) Association between liver stiffness by MRE and fibrosis stage at week 24 in the 60 patients with available data at week 24. (B) Change in liver stiffness by MRE according to fibrosis response from baseline to week 24. rs and p values for (A) by Spearman correlation, and p value for (B) by Wilcoxon rank-sum test. AUC, area under the ROC curve; MRE, magnetic resonance elastography. Journal of Hepatology 2019 70, 133-141DOI: (10.1016/j.jhep.2018.09.024) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Association of MRI-PDFF with histologic steatosis grade and NAS. (A) Association between histologic steatosis grade and NAS with MRI-PDFF at week 24 and (B) change in MRI-PDFF by histologic response from baseline to week 24. rs and p values for (A) by Spearman correlation, and p value for (B) by Wilcoxon rank-sum test. AUC, area under the ROC curve; MRI-PDFF, magnetic resonance imaging-proton density fat fraction; NAS, non-alcoholic fatty liver disease activity score. Journal of Hepatology 2019 70, 133-141DOI: (10.1016/j.jhep.2018.09.024) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Changes in hepatic markers according to reduction in MRE and MRI-PDFF. (A) Changes in hepatic markers according to magnitude of reduction in liver stiffness by MRE from baseline to week 24. (B) Changes in hepatic markers according to magnitude of MRI-PDFF reduction from baseline to week 24. (C) Proportions of patients with improved NAS components according to magnitude of MRI-PDFF reduction from baseline to week 24. p values for (A) and (B) by Wilcoxon rank-sum test, and p values for (C) by Fisher’s exact test. ALT, alanine aminotransferase; ELF, enhanced liver fibrosis score; MRE, magnetic resonance elastography; MRI-PDFF, magnetic resonance imaging-proton density fat fraction; NAS, non-alcoholic fatty liver disease activity score. Journal of Hepatology 2019 70, 133-141DOI: (10.1016/j.jhep.2018.09.024) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions