Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition Pablo F. Soto, MDa,

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Presentation transcript:

Improvement of rejection-induced diastolic abnormalities in rat cardiac allografts with inducible nitric oxide synthase inhibition Pablo F. Soto, MDa, Chao-Xiang Jia, MDc, David G. Rabkin, MDc, Joseph P. Hart, MDc, Yvonne M. Carter, MDb, Michael J. Sardo, BSc, Daphne T. Hsu, MDd, Peter E. Fisher, MDf, David J. Pinsky, MDe, Henry M. Spotnitz, MDc The Journal of Thoracic and Cardiovascular Surgery Volume 120, Issue 1, Pages 39-46 (July 2000) DOI: 10.1067/mtc.2000.107124 Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 The effect of post-transplantation treatment on diastolic pressure volume curves is demonstrated. At pressure intervals averaging 5 and 15 mm Hg, allografts had significantly lower filling volumes versus the 3 other groups (aminoguanidine [AG], dexamethasone [Dex], and isografts; P <.05). Dexamethasone-treated animals had significantly higher filling volumes at all pressure intervals compared with isografts and aminoguanidine-treated animals (P <.001). The Journal of Thoracic and Cardiovascular Surgery 2000 120, 39-46DOI: (10.1067/mtc.2000.107124) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Postmortem LVPVRs for native hearts. No significant differences in normalized LV volume were found among groups. AG, Aminoguanidine; Dex, dexamethasone. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 39-46DOI: (10.1067/mtc.2000.107124) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Myocardial water contents for each group. Aminoguanidine (AG) –treated animals (78.3% ± 0.4%) had similar levels as allografted animals (78.0% ± 0.03%) but significantly greater levels than those of isografted animals (77.1% ± 0.2%) and dexamethasone (Dex) –treated animals (76.7% ± 0.3%, P <.05). The Journal of Thoracic and Cardiovascular Surgery 2000 120, 39-46DOI: (10.1067/mtc.2000.107124) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Representative photomicrographs of the experimental groups. A, Isograft myocytes showing relative paucity of interstitial infiltrate. B, Allograft myocytes showing extensive mononuclear cell interstitial infiltration. C, Aminoguanidine-treated myocytes showing interstitial mononuclear cell infiltration and increased fiber separation consistent with myocardial edema. D, Dexamethasone-treated myocytes with no cellular infiltrate and decreased interstitial separation consistent with the absence of myocardial edema. The Journal of Thoracic and Cardiovascular Surgery 2000 120, 39-46DOI: (10.1067/mtc.2000.107124) Copyright © 2000 American Association for Thoracic Surgery Terms and Conditions