Clinical profile of ceftobiprole, a novel β-lactam antibiotic

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Clinical profile of ceftobiprole, a novel β-lactam antibiotic G.J. Noel Clinical Microbiology and Infection Volume 13, Pages 25-29 (June 2007) DOI: 10.1111/j.1469-0691.2007.01725.x Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Crystal structure of ceftobiprole bound to the active site of Staphylococcus aureus penicillin-binding protein 2′. Courtesy of M. Page, Basilea Pharmaceutica Ltd, Basel, Switzerland. Clinical Microbiology and Infection 2007 13, 25-29DOI: (10.1111/j.1469-0691.2007.01725.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Ceftobiprole activity against (a) Gram-positive (46th ICAAC, abstract E-116) and (b) Gram-negative (Enterobacteriaceae) isolates (15th ECCMID, abstract P-1569). CoNS MR, methicillin-resistant/coagulase-negative staphylococci; CoNS MS, methicillin-susceptible/coagulase-negative staphylococci; MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-susceptible S. aureus. Clinical Microbiology and Infection 2007 13, 25-29DOI: (10.1111/j.1469-0691.2007.01725.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 AUC and Cmax of single ascending doses of ceftobiprole prodrug [3]. Clinical Microbiology and Infection 2007 13, 25-29DOI: (10.1111/j.1469-0691.2007.01725.x) Copyright © 2007 European Society of Clinical Infectious Diseases Terms and Conditions