Colonic transit influences deoxycholic acid kinetics

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Presentation transcript:

Colonic transit influences deoxycholic acid kinetics Martin J. Veysey, Linzi A. Thomas, Anthony I. Mallet, Paul J. Jenkins, G.Michael Besser, Gerard M. Murphy, R.Hermon Dowling Gastroenterology Volume 121, Issue 4, Pages 812-822 (October 2001) DOI: 10.1053/gast.2001.28015 Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 1 Group and paired data for the DCA input rate in nonacromegalic control subjects, acromegalic patients untreated with octreotide (OT), acromegalic patients on long-term octreotide treatment (LTOT), and patients with constipation. Gastroenterology 2001 121, 812-822DOI: (10.1053/gast.2001.28015) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 2 Group and paired data for the DCA pool size in nonacromegalic control subjects, acromegalic patients untreated with octreotide (OT), acromegalic patients on long-term octreotide treatment (LTOT), and patients with constipation. Gastroenterology 2001 121, 812-822DOI: (10.1053/gast.2001.28015) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 3 Excess 13C-DCA, in the DCA pool, in acromegalic patients studied before and during octreotide treatment (n = 5). Gastroenterology 2001 121, 812-822DOI: (10.1053/gast.2001.28015) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 4 Relationship between LBTT and (A) the DCA input rate and (B) the DCA pool size. Gastroenterology 2001 121, 812-822DOI: (10.1053/gast.2001.28015) Copyright © 2001 American Gastroenterological Association Terms and Conditions

Fig. 5 Relationship between the input rate of DCA into the enterohepatic circulation and the proportion of DCA in fasting serum. Gastroenterology 2001 121, 812-822DOI: (10.1053/gast.2001.28015) Copyright © 2001 American Gastroenterological Association Terms and Conditions