Figure 1 Mechanistic classification of lncRNAs

Slides:

Advertisements

Similar presentations

20,000 GENES IN HUMAN GENOME; WHAT WOULD HAPPEN IF ALL THESE GENES WERE EXPRESSED IN EVERY CELL IN YOUR BODY? WHAT WOULD HAPPEN IF THEY WERE EXPRESSED.

Advertisements

STRATEGY FOR GENE REGULATION 1.INFORMATION IN NUCLEIC ACID – CIS ELEMENT CIS = NEXT TO; ACTS ONLY ON THAT MOLECULE 2.TRANS FACTOR (USUALLY A PROTEIN) BINDS.

Chapter 15 Noncoding RNAs. You Must Know The role of noncoding RNAs in control of cellular functions.

GENOM REGULATION BY LONG NONCODING RNA SUPERVISOR: DR.FARAJOLLAHI PRESENTED BY: BAHAREH SADAT RASOULI.

Copyright © 2009 Pearson Education, Inc. Regulation of Gene Expression in Eukaryotes Chapter 17 Lecture Concepts of Genetics Tenth Edition.

Date of download: 11/11/2016 Copyright © The American College of Cardiology. All rights reserved. From: Long Noncoding RNAs: From Clinical Genetics to.

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

LncRNAs exert their effects by diverse mechanisms. LncRNAs exert their effects by diverse mechanisms. (A) lncRNAs can.

Figure 5 A layered approach to the follow-up of patients with acute kidney disease (AKD) Figure 5 | A layered approach to the follow-up of patients with.

Figure 2 Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis Figure 2 | Crosstalk between TGF-β/Smad and other pathways in tissue fibrosis.

Figure 3 LncRNAs in kidney disease

Figure 2 Exosome composition

Figure 3 Energy metabolism regulation, cardiovascular and bone disease in CKD Figure 3 | Energy metabolism regulation, cardiovascular and bone disease.

Figure 4 Expression of coagulation protease receptors in renal cells

Mechanisms of lncRNA function.

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 Cellular processes involved in cancer development

Figure 1 The epigenetic landscape mediates the interplay between stressors and renal dysfunction Figure 1 | The epigenetic landscape mediates the interplay.

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 Pathogenic mechanisms and pathways in ADPKD

“Gene Expression Regulation”

Concept 18.2: Eukaryotic gene expression can be regulated at any stage

Cell Signaling.

Gene Regulation.

Figure 6 The bioavailability of phosphate differs according to the protein source Figure 6 | The bioavailability of phosphate differs according to the.

Figure 7 The efficacy of phosphate-binder therapy

Approaching TERRA Firma: Genomic Functions of Telomeric Noncoding RNA

Figure 2 The network of chronic diseases and their mutual influences

Figure 2 Three distinct mechanisms of activation of

Figure 1 The burden of chronic kidney disease (CKD)

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 Overview of canonical TGF-β/Smad signalling in tissue fibrosis Figure 1 | Overview of canonical TGF-β/Smad signalling in tissue fibrosis. Once.

Figure 2 Molecular pathways involved in the regulation of T-cell differentiation and cytokine production Figure 2 | Molecular pathways involved in the.

Figure 1 Acute kidney injury and chronic kidney disease

Figure 4 The gut–kidney axis, inflammation and cardiovascular disease in CKD Figure 4 | The gut–kidney axis, inflammation and cardiovascular disease in.

Figure 2 Oestrogen receptor signalling pathways

Figure 4 Model of changes in the serum levels

Figure 2 Roles of mTOR complexes in the kidney

Figure 3 Physiological regulation of autophagy in the heart

Figure 4 Potential therapeutic strategies to inhibit TGF-β1/Smad-induced tissue fibrosis Figure 4 | Potential therapeutic strategies to inhibit TGF-β1/Smad-induced.

Figure 1 mTOR complex biology

Figure 1 The coagulation system

Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Gastroenterol. Hepatol. doi: /nrgastro

mRNA Degradation and Translation Control

Figure 4 Diverse molecular mechanisms of long non-coding RNAs

Figure 3 Loss of the glycocalyx leads to podocyte and kidney injury

Nat. Rev. Nephrol. doi: /nrneph

HMGA2, MicroRNAs, and Stem Cell Aging

Figure 1 Involvement of pVHL in cellular physiology and RCC

The Function and Therapeutic Potential of Long Non-coding RNAs in Cardiovascular Development and Disease Clarissa P.C. Gomes, Helen Spencer, Kerrie L.

Figure 3 Serum phosphate level is associated with

Nat. Rev. Nephrol. doi: /nrneph

Figure 3 Regulation of TGF-β1/Smad signalling by microRNAs (miRs) in tissue fibrosis Figure 3 | Regulation of TGF-β1/Smad signalling by microRNAs (miRs)

RNA-DNA Triplex Formation by Long Noncoding RNAs

Nat. Rev. Nephrol. doi: /nrneph

Nat. Rev. Nephrol. doi: /nrneph

Long Noncoding RNAs: Cellular Address Codes in Development and Disease

Nat. Rev. Nephrol. doi: /nrneph

Figure 1 Main triggers of senescence

Long Noncoding RNA in Hematopoiesis and Immunity

Proteins Kinases: Chromatin-Associated Enzymes?

Figure 4 The relationship between the time-dependent changes in the expression of immunoglobulin, mast cell, acute kidney injury (AKI), and fibrillar collagen.

Figure 4 Intracellular distribution and

Figure 2 Histone acetylation regulates gene expression

Molecular Mechanisms of Long Noncoding RNAs

Long Noncoding RNAs in Cell-Fate Programming and Reprogramming

Nat. Rev. Rheumatol. doi: /nrrheum

Figure 1 Relationships between genetic variants, quantitative traits and diseases Figure 1 | Relationships between genetic variants, quantitative traits.

Long Noncoding RNAs in Cancer Pathways

Presentation transcript:

Figure 1 Mechanistic classification of lncRNAs Figure 1 | Mechanistic classification of lncRNAs. a | Signal lncRNAs are transcribed with spatiotemporal precision and expressed in response to developmental cues, according to cellular context or diverse stimuli. b | Decoy lncRNAs regulate transcription by titrating away transcription factors and other proteins from chromatin without exerting any additional functions. c | Guide lncRNAs bind ribonucleoprotein complexes and direct them to chromatin and other specific targets. d | Scaffold lncRNAs interact with multiple partners to form a chromatin modifying complex that either represses or activates transcription. Lorenzen, J. M. & Thum, T. (2016) Long noncoding RNAs in kidney and cardiovascular diseases Nat. Rev. Nephrol. doi:10.1038/nrneph.2016.51