G.S. Markowitz, C. Gelber, V.D. D'agati Kidney International

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An 18-year-old male with hematuria, renal insufficiency, and defective synthesis of type IV collagen G.S. Markowitz, C. Gelber, V.D. D'agati Kidney International Volume 69, Issue 12, Pages 2278-2282 (June 2006) DOI: 10.1038/sj.ki.5000449 Copyright © 2006 International Society of Nephrology Terms and Conditions

Figure 1 (a) A glomerulus with segmental narrow duplication of the GBM (arrows) and a segmental adhesion to Bowman's capsule (periodic acid Schiff, original magnification × 600). (b) Ultrastructural evaluation reveals thickening and lamellation of the GBM, imparting a ‘basket-weave’ appearance (original magnification × 6000). (c) Staining for the α1 chain of type IV collagen reveals high intensity positivity in GBMs, the mesangial matrix, TBMs, and Bowman's capsule (original magnification × 400). (d) Staining for the α5 chain of type IV collagen reveals high-intensity positivity in Bowman's capsule and distal TBMs. No significant positivity is seen in the GBM (original magnification × 200). Kidney International 2006 69, 2278-2282DOI: (10.1038/sj.ki.5000449) Copyright © 2006 International Society of Nephrology Terms and Conditions