Volume 67, Issue 1, Pages (January 2005)

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Presentation transcript:

Volume 67, Issue 1, Pages 237-247 (January 2005) Mild hyperuricemia induces vasoconstriction and maintains glomerular hypertension in normal and remnant kidney rats Laura G. Sanchez-Lozada, Edilia Tapia, Jose Santamaria, Carmen Avila-Casado, Virgilia Soto, Tomas Nepomuceno, Bernardo Rodriguez-Iturbe, Richard J. Johnson, Jaime Herrera-Acosta, Ph. D. Kidney International Volume 67, Issue 1, Pages 237-247 (January 2005) DOI: 10.1111/j.1523-1755.2005.00074.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Effect of afferent arteriole thickening induced by hyperuricemia on hemodynamic parameters in normal rats. Values of serum uric acid positively correlated with AA media/lumen (A). Arteriolopathy was associated with glomerular pressure (B). Thickening of AA negatively correlated with SNGFR (C) and positively correlated with afferent resistance (D). ^;, control; •, oxonic acid; ^, OA+ allopurinol. Kidney International 2005 67, 237-247DOI: (10.1111/j.1523-1755.2005.00074.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Effect of afferent arteriole thickening induced by hyperuricemia in RK rats. Values of serum uric acid positively correlated with AA media/lumen (A). Arteriolopathy was associated with glomerular pressure (B). Tubulointerstitial infiltration of CD5+ cells (lymphocytes) correlated with AA thickening (C). Glomerular pressure correlated with tubulointerstitial fibrosis (D). □, control RK; ▪, oxonic acid; , OA+ allopurinol. Kidney International 2005 67, 237-247DOI: (10.1111/j.1523-1755.2005.00074.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Representative microphotographs of afferent arteriole morphology. PAS stain and alpha-actin smooth muscle antibody (1000×). Normal rats on normal salt diet (A), oxonic acid (C), OA+ allopurinol (E); control (RK) (B), RK + oxonic acid (D), RK + OA + allopurinol (F). Kidney International 2005 67, 237-247DOI: (10.1111/j.1523-1755.2005.00074.x) Copyright © 2005 International Society of Nephrology Terms and Conditions