Detection of Circulating Lung Cancer Cells with Strong Thymidylate Synthase Reactivity in the Peripheral Blood of a Patient with Pulmonary Adenocarcinoma.

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Detection of Circulating Lung Cancer Cells with Strong Thymidylate Synthase Reactivity in the Peripheral Blood of a Patient with Pulmonary Adenocarcinoma Treated with Pemetrexed Daniel C. Christoph, MD, PhD, Andreas-Claudius Hoffmann, MD, Thomas C. Gauler, MD, Bernadette Reyna Asuncion, MD, Heike Loewendick, BSc, Anja Peglow, BSc, Biftu Hassan, Cindy Tran, BSc, Murry W. Wynes, PhD, Martin Schuler, MD, Wilfried E. Eberhard, MD, Fred R. Hirsch, MD, PhD Journal of Thoracic Oncology Volume 7, Issue 4, Pages 766-767 (April 2012) DOI: 10.1097/JTO.0b013e3182460fa9 Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Circulating tumor cells (CTCs) isolated from the peripheral blood of a patient suffering from an adenocarcinoma of the lung stained with an antibody against thymidylate synthase (TS). A, Strongly TS expressing CTC which resembles a proliferating CTC in prophase of mitosis and displays chromosome maturation with condensed chromosomes. B, Weakly TS expressing CTC. C, Strongly TS expressing CTC. Magnification 1:1000 (using an oil immersion objective). The shown immunomagnetic beads have a diameter of 4.5 µm. Journal of Thoracic Oncology 2012 7, 766-767DOI: (10.1097/JTO.0b013e3182460fa9) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Adenocarcinoma cells of the lung from the same patient stained with hematoxylin/eosin (HE) or an antibody against thymidylate synthase (TS) on a 4-µm section of the formalin-fixed paraffin-embedded primary tumor. A, HE staining. B, TS staining. Magnification 1:1000 (using an oil immersion objective). Journal of Thoracic Oncology 2012 7, 766-767DOI: (10.1097/JTO.0b013e3182460fa9) Copyright © 2012 International Association for the Study of Lung Cancer Terms and Conditions