Kaylon L. Bruner-Tran, Ph. D. , Alessandra C. Carvalho-Macedo, M. D

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Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes Kaylon L. Bruner-Tran, Ph.D., Alessandra C. Carvalho-Macedo, M.D., Antoni J. Duleba, M.D., Marta A. Crispens, M.D., Kevin G. Osteen, Ph.D. Fertility and Sterility Volume 93, Issue 8, Pages 2519-2524 (May 2010) DOI: 10.1016/j.fertnstert.2009.05.076 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A–B) Gross and (C–F) microscopic (formalin fixed) analysis of experimental endometriosis in rag2γ(c) mice. Proliferative phase human endometrium was injected intraperitoneally into mice in the presence (A, C, E) and absence (B, D, F) of human leukocytes. Sections shown in C and D were stained with hematoxylin and eosin. Sections shown in E and F underwent immunohistochemical study using an antibody to von Willebrand factor. Magnification: A–B, × 15; C–F, × 100. Fertility and Sterility 2010 93, 2519-2524DOI: (10.1016/j.fertnstert.2009.05.076) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Localization of human immune cells in frozen experimental lesions. (A) Immunofluorescent imaging of CFSE-labeled human immune cells (green) within the human tissue growing in a mouse (human and mouse tissue stained with DAPI, fluoresces blue). (B) Hematoxylin and eosin staining of a near-sister section shown in A. In both frames, the dotted line marks the interface between the mouse (m) and human (h) tissues. Original magnification: ×200. Fertility and Sterility 2010 93, 2519-2524DOI: (10.1016/j.fertnstert.2009.05.076) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions