Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational.

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Presentation transcript:

Effect of the male factor on the clinical outcome of intracytoplasmic sperm injection combined with preimplantation aneuploidy testing: observational longitudinal cohort study of 1,219 consecutive cycles Rossella Mazzilli, M.D., Danilo Cimadomo, M.Sc., Alberto Vaiarelli, M.D., Antonio Capalbo, Ph.D., Lisa Dovere, Ph.D., Erminia Alviggi, M.Sc., Ludovica Dusi, Ph.D., Carlo Foresta, M.D., Francesco Lombardo, M.D., Andrea Lenzi, M.D., Herman Tournaye, M.D., Carlo Alviggi, M.D., Laura Rienzi, M.Sc., Filippo Maria Ubaldi, M.D. Fertility and Sterility Volume 108, Issue 6, Pages 961-972.e3 (December 2017) DOI: 10.1016/j.fertnstert.2017.08.033 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Subanalysis of the embryologic and clinical results by female age at oocyte pick-up. *P<.05 versus N. MII = metaphase II; MMF = moderate male factor; N = normozoospermic; OA = obstructive azoospermia; OAT-S = sever oligoasthenoterazoospermia; NOA = nonobstructive azoospermia. Fertility and Sterility 2017 108, 961-972.e3DOI: (10.1016/j.fertnstert.2017.08.033) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Subanalysis of the embryological and clinical results by number of MII oocytes collected. *P<.05 versus N. Abbreviations as in Figure 1. Fertility and Sterility 2017 108, 961-972.e3DOI: (10.1016/j.fertnstert.2017.08.033) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 (A) Blastocyst morphology and (B) day of biopsy by sperm factor. *P<.05 versus N. MII = metaphase II; MMF = moderate male factor; N = normozoospermic; OA = obstructive azoospermia; OAT-S = severe oligoasthenoterazoospermia; NOA = nonobstructive azoospermia. Fertility and Sterility 2017 108, 961-972.e3DOI: (10.1016/j.fertnstert.2017.08.033) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Distribution of the cycles by (A) female age at oocyte pick-up (OPU), (B) number of MII oocytes collected, and (C) patient. *P<.05 versus N. Abbreviations as in Supplemental Figure 1. Fertility and Sterility 2017 108, 961-972.e3DOI: (10.1016/j.fertnstert.2017.08.033) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 (A) Birth weight and (B) gestational age by sperm factor. SMF = severe male factor (which includes OAT-S, OA, and NOA). Other abbreviations as in Supplemental Figure 1. Fertility and Sterility 2017 108, 961-972.e3DOI: (10.1016/j.fertnstert.2017.08.033) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions