AML Therapy: Wake Up the Guardian and Cut Loose the Executioners

Slides:

Advertisements

Similar presentations

Individualized Medicine from Prewomb to Tomb Eric J. Topol Cell Volume 157, Issue 1, Pages (March 2014) DOI: /j.cell Copyright.

Advertisements

What We Talk About When We Talk About Fat Evan D. Rosen, Bruce M. Spiegelman Cell Volume 156, Issue 1, Pages (January 2014) DOI: /j.cell

Origins of Metastatic Traits Sakari Vanharanta, Joan Massagué Cancer Cell Volume 24, Issue 4, Pages (October 2013) DOI: /j.ccr

Making Proteins in the Powerhouse B. Martin Hällberg, Nils-Göran Larsson Cell Metabolism Volume 20, Issue 2, Pages (August 2014) DOI: /j.cmet

ER-to-Plasma Membrane Tethering Proteins Regulate Cell Signaling and ER Morphology Andrew G. Manford, Christopher J. Stefan, Helen L. Yuan, Jason A. MacGurn,

Evolution of the Cancer Stem Cell Model Antonija Kreso, John E. Dick Cell Stem Cell Volume 14, Issue 3, Pages (March 2014) DOI: /j.stem

The BCL-2 Family Reunion Jerry E. Chipuk, Tudor Moldoveanu, Fabien Llambi, Melissa J. Parsons, Douglas R. Green Molecular Cell Volume 37, Issue 3, Pages.

Fate Restriction and Multipotency in Retinal Stem Cells Lázaro Centanin, Burkhard Hoeckendorf, Joachim Wittbrodt Cell Stem Cell Volume 9, Issue 6, Pages.

The Mitochondrial Basis of Aging Nuo Sun, Richard J. Youle, Toren Finkel Molecular Cell Volume 61, Issue 5, Pages (March 2016) DOI: /j.molcel

Shaping Genetic Alterations in Human Cancer: The p53 Mutation Paradigm Thierry Soussi, Klas G. Wiman Cancer Cell Volume 12, Issue 4, Pages (October.

Restoring cancer's death sentence

A Novel Link between Inflammation and Cancer

Kicking Genomic Profiling to the Curb: How Re-wiring the Phosphoproteome Can Explain Treatment Resistance in Glioma Fred C. Lam, Michael B. Yaffe Cancer.

Kristin G. Anderson, Ingunn M. Stromnes, Philip D. Greenberg

Atsushi Tanaka, Richard J. Youle Molecular Cell

Intravascular Survival and Extravasation of Tumor Cells

“Ring-Fencing” BRCA1 Tumor Suppressor Activity

An Alternative Sugar Fuels AML

Radiotherapy Complements Immune Checkpoint Blockade

Antagonizing ClpP: A New Power Play in Targeted Therapy for AML

Exploiting the Hidden Treasure of Detained Introns

Elodie Pronier, Ross L. Levine Cancer Cell

Volume 31, Issue 5, Pages (May 2017)

Tipping the Balancing ACT

Volume 26, Issue 1, Pages 1-2 (July 2014)

Integrins and Mutant p53 on the Road to Metastasis

Mitochondrial Fusion: Bax to the Fussure

ABT-199: Taking Dead Aim at BCL-2

Integrins and Mutant p53 on the Road to Metastasis

Does CSF1R Blockade Turn into Friendly Fire?

A Radical Role for p38 MAPK in Tumor Initiation

Volume 29, Issue 3, Pages (March 2016)

Supplementary figure 1.

Apoptosis, Up the Ante Cancer Cell

p53 and Metabolism: The GAMT Connection

Apoptosis-targeted therapies for cancer

Autophagy, Apoptosis, and the Influenza Virus M2 Protein

The p27Kip1 tumor suppressor gene: Still a suspect or proven guilty?

Volume 26, Issue 6, Pages (December 2014)

Apoptosis in normal ovaries of women with and without endometriosis

Volume 20, Issue 1, Pages 3-5 (July 2011)

Characterizing the Killer Colorectal Carcinomas

Joshua E. Allen, Wafik S. El-Deiry Gastroenterology

Volume 28, Issue 5, Pages (November 2015)

Lucifer's Labyrinth—Ten Years of Path Finding in Cell Death

The intrinsic apoptotic pathway is a balance between proapoptotic proteins, for example, Bax and Bak and antiapoptotic proteins. The intrinsic apoptotic.

Mismatch Repair-Deficient Cancers Are Targets for Anti-PD-1 Therapy

Volume 102, Issue 1, Pages 1-4 (July 2000)

Apoptosis and acute kidney injury

Alternative Treatments For Melanoma: Targeting BCL-2 Family Members to De-Bulk and Kill Cancer Stem Cells Nabanita Mukherjee, Josianna V. Schwan, Mayumi.

Naoufal Zamzami, Guido Kroemer Current Biology

Death upon a Kiss: Mitochondrial Outer Membrane Composition and Organelle Communication Govern Sensitivity to BAK/BAX-Dependent Apoptosis Thibaud T.

Volume 143, Issue 6, (December 2010)

Apoptosis-targeted therapies for cancer

Manipulation of Host Cell Death Pathways during Microbial Infections

Arnaud Autret, Seamus J. Martin Molecular Cell

RIPK3 Slams the Brake on Leukemogenesis

Splicing and Dicing MYC-Mediated Synthetic Lethality

Khalid S. Mohammad, Theresa A. Guise Cancer Cell

TFIID and MYB Share a Therapeutic Handshake in AML

The End and After: How Dying Cells Impact the Living Organism

Jean-Claude Martinou, Richard J. Youle Developmental Cell

All Roads Lead to the Ribosome

Lesley-Ann Martin, Mitch Dowsett Cancer Cell

“Bak (and Bax) to the Future” — of Primary Melanoma Prognosis?

c-Raf in KRas Mutant Cancers: A Moving Target

The Tribble with APL: A New Road to Therapy

Pharmacological Rescue of p53 in Cancer Therapy: Widening the Sensitive Tumor Spectrum by Targeting MDMX Jean-Christophe Marine Cancer Cell Volume.

Volume 12, Issue 6, Pages (December 2007)

Anthony N. Imbalzano, Stephen N. Jones Cancer Cell

Presentation transcript:

AML Therapy: Wake Up the Guardian and Cut Loose the Executioners Dario C. Altieri Cancer Cell Volume 32, Issue 6, Pages 719-720 (December 2017) DOI: 10.1016/j.ccell.2017.11.010 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Antileukemic Effect of the Combination of Venetoclax Plus RG7388 Simultaneous inhibition of Bcl-2/Bax-Bak complexes (Venetoclax) and reactivation of p53 tumor suppressor function (RG7338) results in kinase-dependent destabilization and proteasomal destruction of anti-apoptotic Bcl-2 family protein, Mcl-1, oligomerization of Bax at the outer mitochondrial membrane, and activation of apoptosis. Cancer Cell 2017 32, 719-720DOI: (10.1016/j.ccell.2017.11.010) Copyright © 2017 Elsevier Inc. Terms and Conditions