Design and Validation of the Biliary Atresia Research Consortium Histologic Assessment System for Cholestasis in Infancy Pierre Russo, John C. Magee,

Slides:

Advertisements

Similar presentations

Irritable Bowel Syndrome and Microscopic Colitis: A Systematic Review and Meta- analysis Eline J.C.A. Kamp, John S. Kane, Alexander C. Ford Clinical Gastroenterology.

Advertisements

MiraLAX Is Not as Effective as GoLytely in Bowel Cleansing Before Screening Colonoscopies Michael Hjelkrem, Joel Stengel, Mark Liu, David P. Jones, Stephen.

Optimizing Diagnosis From the Medical Liver Biopsy

Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis

An Unusual Cause of Small Bowel Obstruction: A Plastic Glove

Abnormal Liver Tests and Fatty Liver on Ultrasound

Flavia D. Mendes, Ayako Suzuki, Schuyler O. Sanderson, Keith D

Incorrect Calculation and Inappropriate Interpretation: Accuracy of International Guidelines for Identifying Significant Fibrosis in e Antigen–Negative.

The Use of Immunoglobulin G4 Immunostaining in Diagnosing Pancreatic and Extrapancreatic Involvement in Autoimmune Pancreatitis Maesha G. Deheragoda,

Reactivation of Hepatitis B With Reappearance of Hepatitis B Surface Antigen After Chemotherapy and Immunosuppression Tara N. Palmore, Neeral L. Shah,

A Rare Cause of Life-Threatening Upper Gastrointestinal Bleeding

Huge Adrenal Hemangioma: A Rare Cause of Deceivingly High Liver Stiffness Measurement by Transient Elastography Grace Lai-Hung Wong, Raymond Kwok, Vincent.

Biomarkers of Reflux Disease

The Use of Immunoglobulin G4 Immunostaining in Diagnosing Pancreatic and Extrapancreatic Involvement in Autoimmune Pancreatitis Maesha G. Deheragoda,

James W.T. Toh, Hasitha Balasuriya, Peter Stewart

Shou–Jiang Tang, Feriyl Bhaijee

A Shocking Cystory Clinical Gastroenterology and Hepatology

Portal Hypertensive Enteropathy in Small-Bowel Capsule Endoscopy

Optimizing Diagnosis From the Medical Liver Biopsy

Diffuse Gastric Wall Thickening: Appearances Can Be Deceptive

Stephen A. Harrison, MD, FACP Clinical Gastroenterology and Hepatology

Laurent Peyrin–Biroulet, Aude Bressenot, Wendy Kampman

An Unusual Cause of Small Bowel Obstruction: A Plastic Glove

Granular Cell Tumor in Colonic Polyp Found on Screening Colonoscopy

Volume 125, Issue 4, Pages (October 2003)

Proximal Esophageal Varices: A Rare Yet Treatable Cause of Hemorrhage

Volume 141, Issue 5, Pages e9 (November 2011)

Atif Saleem, David H. Bruining, Todd H. Baron

A. James Hanje, Lindsay J. Pell, Nicholas A. Votolato, Wendy L

Activity-Based Costing and Management in a Hospital-Based GI Unit

Endoscopic Therapy for Barrett's Esophagus

Cainan Foltz, Williamson Strum

Adequacy of Endoscopic Ultrasound Core Needle Biopsy Specimen of Nonmalignant Hepatic Parenchymal Disease Ferga C. Gleeson, Amy C. Clayton, Lizhi Zhang,

Michel I. Kafrouni, Robert A. Anders, Sumita Verma

Obstructive Jaundice Caused by Intraductal Hepatocellular Carcinoma

Metastatic Malignant Melanoma of the Gastrointestinal Tract

Abnormal Liver Tests and Fatty Liver on Ultrasound

New Models of Gastroenterology Practice

Clinical and Histologic Features of Azithromycin-Induced Liver Injury

Ramesh Kumar, Masiullah, Pintu Kumar Singh

Dushyant Singh, Reetu Singh, Wendell K. Clarkston

Patients With Autoimmune Hepatitis Who Have Antimitochondrial Antibodies Need Long-term Follow-up to Detect Late Development of Primary Biliary Cirrhosis

An Asymptomatic, Radiographically Undetected Hepatocellular Carcinoma That Presented as a Large Retropancreatic Mass Najat Mourra, Lionel Arrive, François.

Proliferating Pilar Tumor of Scalp Metastasizing to Pancreas: Diagnosis With Endoscopic Ultrasound–guided Fine-needle Aspiration Guru Trikudanathan,

An Unusual Presentation of Hematemesis: A Presentation of Maxillary Metastasis From Hepatocellular Carcinoma Ming–Jong Bair, Wei–Yi Lei, Chien–Lin Chen

Harpal S. Dhaliwal, Saroj K. Sinha, Rakesh Kochhar

Hepatic Dysfunction in Sickle Cell Disease: A New System of Classification Based on Global Assessment Philip A. Berry, Timothy J.S. Cross, Swee Lay Thein,

Volume 44, Issue 4, Pages (April 2006)

Gino Caselli, Cecilia Besa, Dahiana Pulgar

Elizabeth Mileti, Philip Rosenthal, Marion G. Peters

Alcohol Use and Cigarette Smoking as Risk Factors for Post–Endoscopic Retrograde Cholangiopancreatography Pancreatitis Anthony T. DeBenedet, Trivellore.

Volume 149, Issue 6, Pages (November 2015)

Hepatic Cyst? Clinical Gastroenterology and Hepatology

Common Bile Duct Carcinoid Mimicking the Clinical, EUS, and ERCP Findings of Cholangiocarcinoma: A Rare but Potentially Curable Cause of Obstructive Jaundice

A 27-Year-Old Woman With Constipation: Diagnosis and Treatment

Anshu Mahajan, Sean C. Kumer, Andrew Y. Wang

Prolapsed Gastric Gastrointestinal Stromal Tumor: A Rare Cause of Biliary Obstruction and Acute Pancreatitis Musa Yilmaz, Juan Ibarra, Benjamin Leon.

Minimal-Change Esophagitis on Narrow-Band Imaging

A 42–Year–Old Woman With a New Diagnosis of Sclerosing Cholangitis

Eric M. Nelsen, Darya Buehler, Patrick R. Pfau

Coagulation in Liver Disease: A Guide for the Clinician

The Liver in Brucellosis

Diagnosis of Primary Splenic Flexure Schwannoma Before Surgery Based on Endoscopic-Ultrasound–Guided Fine-Needle Biopsy Guru Trikudanathan, Sophia Smith,

Coloduodenal Fistula in Crohn’s Disease

Black and White Liver Clinical Gastroenterology and Hepatology

Fulminant Hepatic Failure Secondary to Erlotinib

Adverse Outcomes: Why Bad Things Happen to Good People

Thomas G. Cotter, John S. Van Arnam, John A. Schaffner

Subcapsular Hepatic Fluid Collection Caused by Cardiac Dysfunction

Metastatic Malignant Melanoma of the Gastrointestinal Tract

Presentation transcript:

Design and Validation of the Biliary Atresia Research Consortium Histologic Assessment System for Cholestasis in Infancy Pierre Russo, John C. Magee, John Boitnott, Kevin E. Bove, Trivellore Raghunathan, Milton Finegold, Joel Haas, Ronald Jaffe, Grace E. Kim, Margret Magid, Hector Melin–Aldana, Frances White, Peter F. Whitington, Ronald J. Sokol Clinical Gastroenterology and Hepatology Volume 9, Issue 4, Pages 357-362.e2 (April 2011) DOI: 10.1016/j.cgh.2011.01.003 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 (A) Portal tract expansion with bile duct/ductular proliferation, especially evident at the limiting plate (arrowheads), is noted in this liver biopsy from a 6-week-old infant with BA. Biliary pigment is noted in some ductules (arrows). There is also a cellular infiltrate in the portal spaces that appears to be largely extramedullary hematopoiesis. The surrounding lobule shows little change, except for mild extramedullary hematopoiesis and focal hepatocellular multinucleation. This was rated as consistent with BA by 10 of 10 pathologists. H&E stain; original magnification, ×100. (B) Wedge biopsy from a 2-week-old infant with BA. Portal tracts are mildly expanded by a cellular infiltrate, with only minimal bile duct/ductular proliferation. Only 2 of 9 pathologists favored diagnosis of BA. H&E stain; original magnification, ×100. (C) Biopsy from a case of INH categorized as obstructive by the pathologists. There are portal tract expansion and fibrosis with bile ductular proliferation. Ten of 10 pathologists favored diagnosis of obstruction; however, clinical follow-up confirmed absence of biliary obstruction. H&E stain; original magnification, ×200. (D) Needle biopsy from case of alpha1-antitrypsin deficiency. There are portal expansions and fibrosis, with bile ductular proliferation and presence of rare bile plugs. Eight of 10 pathologists favored diagnosis of BA. H&E stain; original magnification, ×100. Clinical Gastroenterology and Hepatology 2011 9, 357-362.e2DOI: (10.1016/j.cgh.2011.01.003) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 Correlation of individual pathologists' diagnosis in cases of BA. Clinical Gastroenterology and Hepatology 2011 9, 357-362.e2DOI: (10.1016/j.cgh.2011.01.003) Copyright © 2011 AGA Institute Terms and Conditions