Inflammatory reaction and capillary leak syndrome related to cardiopulmonary bypass in neonates undergoing cardiac operations Marie-Christine Seghaye,

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Presentation transcript:

Inflammatory reaction and capillary leak syndrome related to cardiopulmonary bypass in neonates undergoing cardiac operations Marie-Christine Seghaye, MDa, Ralph G. Grabitz, MDa, Jean Duchateau, MDb, Sabine Bussea, Sabine Däbritz, MDc, Dieter Koch, MDa, Gerhard Alzen, MDd, Helmut Hörnchen, MDe, Bruno J. Messmer, MDc, Götz von Bernuth, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 3, Pages 687-697 (September 1996) DOI: 10.1016/S0022-5223(96)70053-3 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Course of albumin concentrations before, during, and after CPB in neonates with (black) and without (white) CLS. *Significant difference between the two groups (p < 0.05). CCA, Complete circulatory arrest; recirc, recirculation; revent, reventilation; rewarm, rewarming; prota, protamine. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 687-697DOI: (10.1016/S0022-5223(96)70053-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Relative concentration (expressed as percentage of the prebypass value) of retinol-binding protein (RBP), albumin (ALB), immunoglobulin G (IgG), and α2-macroglobulin (α2 -MG) 10 minutes after institution of CPB in neonates with (black) and without (white) CLS. *Significant difference between the two groups (p < 0.05). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 687-697DOI: (10.1016/S0022-5223(96)70053-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Course of C3 before, during, and after CPB in neonates with (black) and without (white) CLS. Abbreviations as in Fig. 1. PO, Postoperatively. *Significant difference between the two groups (p < 0.05). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 687-697DOI: (10.1016/S0022-5223(96)70053-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Course of C4 before, during, and after CPB in neonates with (black) and without (white) CLS. Abbreviations as in Fig. 1. PO, Postoperatively. *Significant difference between the two groups (p < 0.05). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 687-697DOI: (10.1016/S0022-5223(96)70053-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Course of C1 inhibitor (C1-inh) before, during, and after CPB in neonates with (black) and without (white) CLS. Abbreviations as in Fig. 1. PO, Postoperatively. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 687-697DOI: (10.1016/S0022-5223(96)70053-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 6 Course of TNF-α before, during, and after CPB in neonates with (black) and without (white) capillary leak syndrome. Abbreviations as in Fig. 1. PO, Postoperatively. *Significant difference between the two groups (p < 0.05). The Journal of Thoracic and Cardiovascular Surgery 1996 112, 687-697DOI: (10.1016/S0022-5223(96)70053-3) Copyright © 1996 Mosby, Inc. Terms and Conditions