Potential impact of complement regulator deficiencies on hemolytic reactions due to minor ABO-mismatched transfusions by Priyanka Pandey, Waseem Q. Anani,

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Potential impact of complement regulator deficiencies on hemolytic reactions due to minor ABO-mismatched transfusions by Priyanka Pandey, Waseem Q. Anani, Jerome L. Gottschall, and Gregory A. Denomme BloodAdv Volume 1(23):1977-1982 October 24, 2017 © 2017 by The American Society of Hematology

Priyanka Pandey et al. Blood Adv 2017;1:1977-1982 © 2017 by The American Society of Hematology

Flow cytometric evaluation of MIRL Flow cytometric evaluation of MIRL. The graphs represent fluorescence counts on the y-axis vs channel PE (MIRL) on the x-axis. Flow cytometric evaluation of MIRL. The graphs represent fluorescence counts on the y-axis vs channel PE (MIRL) on the x-axis. (A) Untreated group A1 RBCs expressing MIRL, (B) AET-treated group A1 RBCs lost MIRL and have an overlapping profile with the isotype control and unstained RBCs. Green peak, isotope control; pink peak, unstained control; purple peak, MIRL-positive cells. Priyanka Pandey et al. Blood Adv 2017;1:1977-1982 © 2017 by The American Society of Hematology

Antibody-mediated lysis of PNH clone. Antibody-mediated lysis of PNH clone. The graphs represent MIRL-positive cells on the y-axis in a PE channel. The x-axis represents a blank fluorescein isothiocyanate channel. A group O RBC sample with a clone of patient PNH RBCs was used for the study. (A) Negative control: RBCs sensitized with pooled AB plasma. (B) An 86% reduction in the size of PNH clone was observed upon sensitization of RBCs with anti-I because of the lysis of PNH clone. Priyanka Pandey et al. Blood Adv 2017;1:1977-1982 © 2017 by The American Society of Hematology