Cerebral Hemodynamics at Altitude: Effects of Hyperventilation and Acclimatization on Cerebral Blood Flow and Oxygenation Matthew R. Sanborn, MD, Mark.

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Presentation transcript:

Cerebral Hemodynamics at Altitude: Effects of Hyperventilation and Acclimatization on Cerebral Blood Flow and Oxygenation Matthew R. Sanborn, MD, Mark E. Edsell, MB, ChB, Meeri N. Kim, MA, Rickson Mesquita, PhD, Mary E. Putt, ScD, Chris Imray, MB, BS, Heng Yow, MB, ChB, Mark H. Wilson, MB, BChir, Arjun G. Yodh, PhD, Mike Grocott, MB, ChB, Daniel S. Martin, MB, ChB Wilderness & Environmental Medicine Volume 26, Issue 2, Pages 133-141 (June 2015) DOI: 10.1016/j.wem.2014.10.001 Copyright © 2015 Wilderness Medical Society Terms and Conditions

Figure 1 Changes in cerebral (Scto2) and peripheral (Spo2) oxygenation with acclimatization. Both peripheral and cerebral oxygenation decreased after 2 days at 4559 m. After further acclimatization, peripheral oxygenation rebounded, whereas cerebral oxygenation continued to decline. Wilderness & Environmental Medicine 2015 26, 133-141DOI: (10.1016/j.wem.2014.10.001) Copyright © 2015 Wilderness Medical Society Terms and Conditions

Figure 2 Scatter-plot demonstrating the percentage change induced by hyperventilation (HV) in peak systolic velocity (PSV) in the middle cerebral artery (MCA) measured by transcranial Doppler ultrasound (TCD; A) and percentage change in relative cerebral blood flow (rCBF) measured by diffuse correlation spectroscopy (DCS; B) at sea level (time 0) and on days 2 and 7 after arrival at 4559 m. Wilderness & Environmental Medicine 2015 26, 133-141DOI: (10.1016/j.wem.2014.10.001) Copyright © 2015 Wilderness Medical Society Terms and Conditions

Figure 3 Percentage reduction in peak systolic velocity (PSV) measured by transcranial Doppler or relative cerebral blood flow (rCBF) measured by diffuse correlation spectroscopy (DCS) after hyperventilation to 50% of baseline end-tidal CO2. Wilderness & Environmental Medicine 2015 26, 133-141DOI: (10.1016/j.wem.2014.10.001) Copyright © 2015 Wilderness Medical Society Terms and Conditions