IRNA-PseColl: Identifying the Occurrence Sites of Different RNA Modifications by Incorporating Collective Effects of Nucleotides into PseKNC  Pengmian.

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Presentation transcript:

iRNA-PseColl: Identifying the Occurrence Sites of Different RNA Modifications by Incorporating Collective Effects of Nucleotides into PseKNC  Pengmian Feng, Hui Ding, Hui Yang, Wei Chen, Hao Lin, Kuo-Chen Chou  Molecular Therapy - Nucleic Acids  Volume 7, Pages 155-163 (June 2017) DOI: 10.1016/j.omtn.2017.03.006 Copyright © 2017 The Author(s) Terms and Conditions

Figure 1 A Schematic Drawing to Show the Three Types of Modifications that May Simultaneously Occur in an RNA Sequence Three types of modifications (m1A, m6A, and m5C) are shown. Molecular Therapy - Nucleic Acids 2017 7, 155-163DOI: (10.1016/j.omtn.2017.03.006) Copyright © 2017 The Author(s) Terms and Conditions

Figure 2 A Graphical Illustration to Show the Performances of iRNA-PseColl in Identifying m1A, m6A, and m5C Modification Sites, Respectively The performances are illustrated by means of the ROC curves.35,36 The area under the ROC curve is called AUROC. The greater the AUROC value is, the better the performance will be. See the text for further explanation. Molecular Therapy - Nucleic Acids 2017 7, 155-163DOI: (10.1016/j.omtn.2017.03.006) Copyright © 2017 The Author(s) Terms and Conditions

Figure 3 An Illustration to Show the Process of Collecting the RNA Samples by Sliding the (2ξ + 1) -nt Scaled Window along an RNA Sequence Adapted from Chou65 with permission. See the text for further explanation. Molecular Therapy - Nucleic Acids 2017 7, 155-163DOI: (10.1016/j.omtn.2017.03.006) Copyright © 2017 The Author(s) Terms and Conditions

Figure 4 Illustration to Show the Structure of Paired Nucleic Acid Residues Left: A-U pair bonded to each other with two hydrogen bonds. Right: G-C pair with three hydrogen bonds. Adapted from Chou87 with permission. Molecular Therapy - Nucleic Acids 2017 7, 155-163DOI: (10.1016/j.omtn.2017.03.006) Copyright © 2017 The Author(s) Terms and Conditions