Maximal Estimated Cardiorespiratory Fitness, Cardiometabolic Risk Factors, and Metabolic Syndrome in the Aerobics Center Longitudinal Study  Conrad P. Earnest, PhD, Enrique G. Artero, PhD, Xuemei Sui, MD, MPH, PhD, Duck-chul Lee, PhD, Timothy S. Church, MD, MPH, PhD, Steven N. Blair, PED  Mayo Clinic Proceedings  Volume 88, Issue 3, Pages 259-270 (March 2013) DOI: 10.1016/j.mayocp.2012.11.006 Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Data represent the adjusted mean (SEM) for men (left) and women (right) for averaged metabolic syndrome summed z scores on the basis of 3 statistical models. Model 1 was adjusted for age and examination year. Model 2 was adjusted for age, examination year, body mass index, smoking (current smoker or not), alcohol intake (>14 drinks per week for men and >7 drinks per week for women or not), and family history of cardiovascular disease. Model 3 was adjusted for age, examination year, body mass index, physical activity (active or inactive), smoking (current smoker or not), alcohol intake (>14 drinks per week for men and >7 drinks per week for women or not), hypercholesterolemia, hypertension and diabetes (present or not for each), and family history of cardiovascular disease. ∗P<.001; ∗∗P=.02; †P=.04; ††P=.008. Mayo Clinic Proceedings 2013 88, 259-270DOI: (10.1016/j.mayocp.2012.11.006) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Data present the quadratic regression of individual metabolic syndrome summed z scores and accompanying 95% CIs vs estimated cardiorespiratory fitness (ie, metabolic equivalents [METs]) from graded exercise testing for men (A) and women (B). Mayo Clinic Proceedings 2013 88, 259-270DOI: (10.1016/j.mayocp.2012.11.006) Copyright © 2013 Mayo Foundation for Medical Education and Research Terms and Conditions