Regulation of pentraxin-3 by antioxidants

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Presentation transcript:

Regulation of pentraxin-3 by antioxidants A.L. Hill, D.A. Lowes, N.R. Webster, C.C. Sheth, N.A.R. Gow, H.F. Galley British Journal of Anaesthesia Volume 103, Issue 6, Pages 833-839 (December 2009) DOI: 10.1093/bja/aep298 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 (a) Plasma PTX3 concentrations in 15 patients with sepsis and 11 healthy subjects. Squares are females, circles are males. (b) Data sets compared using Mann–Whitney U-test. Plasma PTX3 concentrations according to APACHE II score quartile in 15 patients with sepsis. British Journal of Anaesthesia 2009 103, 833-839DOI: (10.1093/bja/aep298) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 Plasma total antioxidant capacity in 15 patients with sepsis and 11 healthy subjects. Data sets compared using Mann–Whitney U-test. British Journal of Anaesthesia 2009 103, 833-839DOI: (10.1093/bja/aep298) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 The effect of different inflammatory stimuli on PTX3 expression by human endothelial cells in vitro. Note the different scales on the two graphs. Data are from four replicate experiments conducted in triplicate. LPS, lipopolysaccharide (2 µg ml−1); PepG, peptidoglycan G (20 µg ml−1); TNFα, tumour necrosis factor α (10 ng ml−1); IL-1β, interleukin-1β (20 ng ml−1); C. albicans, heat-killed Candida albicans cells (MOI=3). British Journal of Anaesthesia 2009 103, 833-839DOI: (10.1093/bja/aep298) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 4 The effect of antioxidants on PTX3 and NFκB expression in human endothelial cells treated with TNFα and IL-1β. Data are from four replicate experiments conducted in triplicate and were analysed by the Kruskal–Wallis with Mann–Whitney U post hoc testing. *Significantly lower than cells without antioxidant (P<0.001). British Journal of Anaesthesia 2009 103, 833-839DOI: (10.1093/bja/aep298) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions