Orthostatic Effects of Midodrine Versus L-NAME on Cerebral Blood Flow and the Renin- Angiotensin-Aldosterone System in Tetraplegia Jill M. Wecht, EdD,

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Orthostatic Effects of Midodrine Versus L-NAME on Cerebral Blood Flow and the Renin- Angiotensin-Aldosterone System in Tetraplegia Jill M. Wecht, EdD, Miroslav Radulovic, MD, Dwindally Rosado-Rivera, EdD, Run-Lin Zhang, MD, Michael F. LaFountaine, EdD, William A. Bauman, MD Archives of Physical Medicine and Rehabilitation Volume 92, Issue 11, Pages 1789-1795 (November 2011) DOI: 10.1016/j.apmr.2011.03.022 Copyright © 2011 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 1 Average supine BL, supine postdrug, and post-HUT after no drug (open circles), L-NAME dose of 1.0mg/kg (closed squares), and midodrine dose of 10mg (asterisks) for (A) MAP (mmHg), (B) CBF (cm/s), (C) renin (pg/mL), and (D) aldosterone (pg/mL). Archives of Physical Medicine and Rehabilitation 2011 92, 1789-1795DOI: (10.1016/j.apmr.2011.03.022) Copyright © 2011 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 2 Individual change from BL to post-HUT after no drug (open bars), L-NAME dose of 1.0mg/kg (closed bars), and midodrine dose of 10mg (hatched bars) in (A) MAP, (B) CBF, (C) renin, and (D) aldosterone. Archives of Physical Medicine and Rehabilitation 2011 92, 1789-1795DOI: (10.1016/j.apmr.2011.03.022) Copyright © 2011 American Congress of Rehabilitation Medicine Terms and Conditions

Fig 3 Relationship between the change in MAP (mmHg) and CBF (cm/s) post-HUT among the no drug (open squares), L-NAME (triangles), and midodrine (asterisks) trials. The overall association was significant (r2=0.592; P<0.001). Archives of Physical Medicine and Rehabilitation 2011 92, 1789-1795DOI: (10.1016/j.apmr.2011.03.022) Copyright © 2011 American Congress of Rehabilitation Medicine Terms and Conditions