Denis W. Harkin, MD, Aires A. B

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Ischemic preconditioning before lower limb ischemia—reperfusion protects against acute lung injury Denis W. Harkin, MD, Aires A.B. Barros D'Sa, MD, Kevin McCallion, PhD, Margaret Hoper, PhD, F.Charles Campbell, MD Journal of Vascular Surgery Volume 35, Issue 6, Pages 1264-1273 (June 2002) DOI: 10.1067/mva.2002.121981 Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 1 Systemic interleukin-6 (IL-6; pg/mL) in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). Data represent median (interquartile range). *P <.003 compared with control. †P <.01 compared with control. ‡P <.001 compared with ischemic preconditioning and ischemic-reperfusion. Journal of Vascular Surgery 2002 35, 1264-1273DOI: (10.1067/mva.2002.121981) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 2 Systemic tumor necrosis factor-alpha (TNF-alpha; pg/mL) in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). No significant differences between groups (P <.02). Data represent median (interquartile range). Journal of Vascular Surgery 2002 35, 1264-1273DOI: (10.1067/mva.2002.121981) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 3 A, Pulmonary artery pressure (mm Hg) in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). *P <.05 compared with control. †P <.001 compared with control. ‡P <.001 compared with ischemic preconditioning and ischemia-reperfusion. B, Arterial PO2 (mm Hg) in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). *P <.05 compared with control and ischemic preconditioning and ischemia-reperfusion. †P <.01 compared with control. ‡P <.005 compared with ischemic preconditioning and ischemia-reperfusion. C, Alveolar-arterial gradient in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). *P <.05 compared with control. †P <.03 compared with ischemic preconditioning and ischemia-reperfusion. Data represent mean ± standard error of mean. With repeated two-way analysis of variance (time and group): *P <.0001. †P <.0001. ‡P <.034. With post hoc Dunnett T3 test: *P <.05. †P <.05. ‡P <.01. Journal of Vascular Surgery 2002 35, 1264-1273DOI: (10.1067/mva.2002.121981) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 4 A, Lung myeloperoxidase (U/g) in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). *P <.01 compared with control. †P <.02 compared with ischemic preconditioning and ischemia-reperfusion. B, Lung wet-to-dry ratio in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). *P <.0001 compared with control. Data represent median (interquartile range). Journal of Vascular Surgery 2002 35, 1264-1273DOI: (10.1067/mva.2002.121981) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions

Fig. 5 Circulating phagocytic cell priming (% maximum) in control group, ischemia-reperfusion group (I/R), and ischemic preconditioning and ischemia-reperfusion group (IPC + I/R). *P <.05 compared with control. †P <.01 compared with ischemic preconditioning and ischemia-reperfusion. Data represent mean ± standard error of mean. Journal of Vascular Surgery 2002 35, 1264-1273DOI: (10.1067/mva.2002.121981) Copyright © 2002 Society for Vascular Surgery and The American Association for Vascular Surgery Terms and Conditions