Quinaprilat during cardioplegic arrest in the rabbit to prevent ischemia-reperfusion injury Peter Korn, MDa, Andreas Kröner, MDb, Jan Schirnhofer, MDb,

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Presentation transcript:

Quinaprilat during cardioplegic arrest in the rabbit to prevent ischemia-reperfusion injury Peter Korn, MDa, Andreas Kröner, MDb, Jan Schirnhofer, MDb, Seth Hallström, PhDb, Oliver Bernecker, MDa, Rudolf Mallinger, MDc, Maximilian Franz, BSa, Harald Gasser, BSb, Ernst Wolner, MDa, Bruno K. Podesser, MDa The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 2, Pages 352-360 (August 2002) DOI: 10.1067/mtc.2002.121676 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Semsroth and Fellner (row 1); Bernecker, Podesser, Franz, and Trescher (row 2); Korn (missing; presently at Cornell University) The Journal of Thoracic and Cardiovascular Surgery 2002 124, 352-360DOI: (10.1067/mtc.2002.121676) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Experimental protocol. Drugs were admixed with blood fractions of respective cardioplegic infusions and with perfusates of subsequent reperfusion. LD, Preischemic Langendorff mode; WH, preischemic working-heart mode; rLD, Langendorff mode during reperfusion; rWH, working-heart mode during reperfusion; Ind, induction of cardioplegia; Re, reinfusion; IQ, ischemia quinaprilat group; ARG, arginine group; PQ, reperfusion quinaprilat group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 352-360DOI: (10.1067/mtc.2002.121676) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Postischemic recovery of hemodynamic parameters. Time points define time in minutes elapsed in Langendorff (rLD) and working-heart (rWH) modes respectively during reperfusion; Recovery denotes percentage referenced to preischemic baseline. Bar heights represent mean; error bars represent SEM. Diagonally filled bars, Ischemia quinaprilat group; white bars, reperfusion quinaprilat group; dotted bars, arginine group; black bars, control group. A. External heart work. Asterisk indicates P <.01; dagger indicates P <.001; double dagger indicates P =.012. B. Coronary flow. Asterisk indicates P =.018 vs control group and P =.029 vs reperfusion quinaprilat group; dagger indicates P =.023 vs control group and P =.028 vs reperfusion quinaprilat group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 352-360DOI: (10.1067/mtc.2002.121676) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Mitochondrial ultrastructure. Representative photomicrographs (original magnification × 45,000) depicting range of observed postischemic damages; grading as defined in text. A, No discernable damage (grade 0). B, Light clearing of matrix with loss of granules (grade 1). C, Additional swelling and partial fragmentation of cristae (grade 2). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 352-360DOI: (10.1067/mtc.2002.121676) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions