Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study

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Loci Related to Metabolic-Syndrome Pathways Including LEPR,HNF1A, IL6R, and GCKR Associate with Plasma C-Reactive Protein: The Women's Genome Health Study Paul M. Ridker, Guillaume Pare, Alex Parker, Robert Y.L. Zee, Jacqueline S. Danik, Julie E. Buring, David Kwiatkowski, Nancy R. Cook, Joseph P. Miletich, Daniel I. Chasman The American Journal of Human Genetics Volume 82, Issue 5, Pages 1185-1192 (May 2008) DOI: 10.1016/j.ajhg.2008.03.015 Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 1 Quantile-Quantile Plot of Actual and Expected p Values for Association with CRP The American Journal of Human Genetics 2008 82, 1185-1192DOI: (10.1016/j.ajhg.2008.03.015) Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 2 p Values for the Association of Individual SNPs with Plasma CRP Levels According to Chromosome Number and Position (Top) Data for study participants with CRP levels < 10 mg/l. (Bottom) Data for the full study cohort. The red horizontal line corresponds to a p value of 10−8. The American Journal of Human Genetics 2008 82, 1185-1192DOI: (10.1016/j.ajhg.2008.03.015) Copyright © 2008 The American Society of Human Genetics Terms and Conditions

Figure 3 Genomic Context for Each of Seven Loci with Genome-wide Association with CRP Levels (A) LEPR locus; (B) CRP locus; (C) IL6R locus; (D) GCKR locus; (E) gene-desert region on 12q23.2; (F) HNF1A locus; (G) APOE locus. Upper panel: Genes from RefSeq release 25. Only one isoform is shown when multiple splicing variants are known. Lower panel: SNPs are plotted according to their physical location with the y axis, indicating p values for association with CRP (red dots). Also shown is the genetic distance in cM from the lowest p value SNP for each locus (light-gray line), along with the position of recombination hotspots (light-gray vertical bars). Recombination rates and hotspots are based on HapMap data.32,33 The American Journal of Human Genetics 2008 82, 1185-1192DOI: (10.1016/j.ajhg.2008.03.015) Copyright © 2008 The American Society of Human Genetics Terms and Conditions