Coiled Bodies and Gems: Janus or Gemini?

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Coiled Bodies and Gems: Janus or Gemini? A. Gregory Matera, Mark R. Frey The American Journal of Human Genetics Volume 63, Issue 2, Pages 317-321 (August 1998) DOI: 10.1086/301992 Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 1 CBs and gems colocalize in most interphase cell types. HeLa-ATCC cells were fixed without detergent preextraction and then stained with anti-p80 coilin (coiled bodies are red) and anti-SMN (gems are green) antibodies. The twin structures in this cell type show complete overlap, as revealed by the yellow signal. Another strain of HeLa (HeLa-PV; Liu et al. 1996, 1997) often displays separate SMN and/or coilin foci (see text). In addition to the nuclear gem/CB staining, the SMN antibody localizes to the cytoplasm. The American Journal of Human Genetics 1998 63, 317-321DOI: (10.1086/301992) Copyright © 1998 The American Society of Human Genetics Terms and Conditions