Sherman J. Silber, M.D. Fertility and Sterility

Slides:

Advertisements

Similar presentations

Akanksha Mehta, M. D. , Alexander Bolyakov, M. S. , Peter N

Advertisements

Male infertility: a biomarker of individual and familial cancer risk

Effect of chronic hypertension on assisted pregnancy outcomes: a population-based study in Ontario, Canada Natalie Dayan, M.D., Andrea Lanes, M.Sc.,

Successful pregnancy and delivery of two sets of monozygotic twins after intracytoplasmic sperm injection and embryo transfer: case report and literature.

Edward G. Hughes, M.B., F.R.C.S.(C.), Deirdre DeJean, M.Sc.

Infertility evaluation and treatment among women in the United States

Fernando Zegers-Hochschild, M.D. Fertility and Sterility

Michael M. Alper, M.D. Fertility and Sterility

Zhi-Yong Yang, M.D., Ri-Cheng Chian, Ph.D. Fertility and Sterility

Hepatitis and reproduction

Azoospermia: is sample centrifugation indicated

Viviana Granados-Gonzalez, M. Sc. , Isabelle Aknin-Seifer, M. D

Genetic risks of intracytoplasmic sperm injection in the treatment of male infertility: recommendations for genetic counseling and screening Mark D Johnson,

Live birth of twins derived from zona-free oocytes

Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis Juan Wen, B.S., Jie Jiang, B.S.,

Management of the first in vitro fertilization cycle for unexplained infertility: a cost- effectiveness analysis of split in vitro fertilization-intracytoplasmic.

Trends in clinical reproductive medicine research: 10 years of growth

Neuromotor development and mental health at 5

Reproductive outcomes of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with high levels of DNA fragmentation in semen:

Akanksha Mehta, M. D. , Alexander Bolyakov, M. S. , Peter N

Oocyte cryopreservation

Ramadan Saleh, M. D. , Reda Z. Mahfouz, M. D. , Ashok Agarwal, Ph. D

Reevaluation of azoospermic factor c microdeletions using sequence-tagged site markers with confirmed physical positions from the GenBank database Masato.

Reply of the Authors Fertility and Sterility

Gadolinium radiologic contrast is a useful alternative for hysterosalpingography in patients with iodine allergy Dorette Noorhasan, M.D., Michael J.

Mieke Carine Wim Eeckhaut, Ph.D. Fertility and Sterility

Limitations on the compensation of gamete donors: a public opinion survey Malinda S. Lee, M.D., M.B.A., Leslie V. Farland, Sc.D., Stacey A. Missmer, Sc.D.,

Use of testicular versus ejaculated sperm for intracytoplasmic sperm injection among men with cryptozoospermia: a meta-analysis Nikita Abhyankar, M.B.ChB.,

Imprinting disorders and assisted reproductive technology

Male infertility: a biomarker of individual and familial cancer risk

Clomiphene citrate at 50: the dawning of assisted reproduction

Normal birth after single-embryo transfer in a patient with excessive polypronuclear zygote formation following in vitro fertilization and intracytoplasmic.

Inequity between male and female coverage in state infertility laws

Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis Aylin Pelin Cil, M.D., Heejung Bang, Ph.D.,

Ongoing twin pregnancy after rescue intracytoplasmic sperm injection of unfertilized abnormal oocytes Navid Esfandiari, D.V.M., Ph.D., H.C.L.D., E. Anne.

Akanksha Mehta, M.D., Darius A. Paduch, M.D., Ph.D.

Evaluation of diagnostic testis biopsy and the repetition of testicular sperm extraction surgeries in infertility patients Alayman Hussein, M.B.B.C.H.,

Complications after fertility-preserving radical trachelectomy

Transmissible microdeletion of the Y-chromosome encompassing two DAZ copies, four RBMY1 copies, and both PRY copies Ingrid Plotton, M.D., Ph.D., Claude.

Poor sperm quality affects clinical outcomes of intracytoplasmic sperm injection in fresh and subsequent frozen–thawed cycles: potential paternal effects.

Effect of treatment of a previous ectopic pregnancy on in vitro fertilization– intracytoplasmic sperm injection outcomes: a retrospective cohort study

Veronica Bertini, Ph. D. , Angelo Valetto, Ph. D. , Angela Uccelli, Ph

Zsolt P. Nagy, M. D. , Ph. D. , Laura F. Rienzi, Ph. D. , Filippo M

Complex chromosome abnormality in patients with in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI) S.P. Weng, T.C.J. Wu, S.P. Kang,

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin Samuel S. Thatcher, M.D., Ph.D., Elizabeth M.

Pregnancy loss in pregnancies conceived after in vitro oocyte maturation, conventional in vitro fertilization, and intracytoplasmic sperm injection William.

Intracytoplasmic sperm injection: a novel selection method for sperm with normal frequency of chromosomal aneuploidies Attila Jakab, M.D., Denny Sakkas,

Fertility and Sterility: an evaluation

Physical health at 5.5 years of age of term-born singletons after intracytoplasmic sperm injection: results of a prospective, controlled, single-blinded.

Cognitive development of singletons born after intracytoplasmic sperm injection compared with in vitro fertilization and natural conception Marjolein.

Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss Lia A. Bernardi, M.D., Ronald N. Cohen, M.D., Mary D. Stephenson, M.D.,

Sperm deoxyribonucleic acid fragmentation as a prognostic indicator of assisted reproductive technology outcome Mehdi Benchaib, M.D., Ph.D., Jacqueline.

Counteraction during movement of spermatozoa by Trichomonas vaginalis observed by visual image analysis: a possible cause of female infertility Viroj.

Current evaluation of amenorrhea

Genetic evaluation procedures at sperm banks in the United States

GR/GR deletions within the azoospermia factor c region on the Y chromosome might not be associated with spermatogenic failure Celia Ravel, M.D., Sandra.

A simplified novel laparoscopic formation of neovagina for cases of Mayer-Rokitansky- Küster-Hauser syndrome Atef Mohammad Darwish, M.D. Fertility and.

Shilin Zhang, M. D. , Tao Wang, M. D. , Jun Yang, M. D. , Zhuo Liu, M

Variability in testis biopsy interpretation: implications for male infertility care in the era of intracytoplasmic sperm injection Matthew R. Cooperberg,

David H. Barad, M.D., M.S., Norbert Gleicher, M.D.

In vitro sildenafil citrate use as a sperm motility stimulant

Saad Elzanaty, M.D., Ph.D., Johan Malm, M.D., Ph.D.

Behavioral, cognitive, and motor performance and physical development of five-year-old children who were born after intracytoplasmic sperm injection with.

Are sperm DNA fragmentation, hyperactivation, and hyaluronan-binding ability predictive for fertilization and embryo development in in vitro fertilization.

Brooks A. Keel, Ph.D., H.C.L.D.(A.B.B.) Fertility and Sterility

Contact among families who share the same sperm donor

Coital frequency and infertility: which male factors predict less frequent coitus among infertile couples? Nathan Perlis, M.D., Kirk C. Lo, M.D., Ethan.

Endometrial polyps affect uterine receptivity

Mohamed Fawzy, M. D. , Mai Emad, B. Sc. , Mohamed Y. AbdelRahman, M. D

Numerical chromosome anomalies detected in paternally derived pronuclei of tripronuclear zygotes after intracytoplasmic sperm injection Ervin Macas,

Presentation transcript:

The Y chromosome in the era of intracytoplasmic sperm injection: a personal review Sherman J. Silber, M.D. Fertility and Sterility Volume 95, Issue 8, Pages 2439-2448.e5 (June 2011) DOI: 10.1016/j.fertnstert.2011.05.070 Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Early map of major Y chromosome deletions in azoospermic men and the diversity of pathologic defects (3). Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Simplified diagram of the main areas for Y chromosome microdeletions, including some that are less frequently studied, such as B2-B3 (106). Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Diagram of DNA sequence boundaries of AZFc deletion and the mechanism of AZFc deletion (2). Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Y deletions are transmitted to all male intracytoplasmic sperm injection (ICSI) offspring. The top lines show the normal Y chromosome of the infertile male’s father. The next lines show the AZFc deletions of the infertile male and the identical AZFc deletions of his male ICSI offspring (9). Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 A theoretical model showing that eventually the sperm count will continue to go down and reach zero in 10,000 years because of intracytoplasmic sperm injection (ICSI) (49) (references are as provided in the original print article). Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Diagram showing the evolutionary accumulation of male-specific genes to the Y chromosome by transposition, retroposition, and persistence (15, 138). Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Evolution of Y chromosome from what was originally a pair of ordinary autosomes 300,000,000 years ago. Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 4 All “male-benefit” spermatogenic genes on the Y chromosome have accumulated in ampliconic regions of repeat DNA sequences and inverted repeat DNA sequences (8) (references are as provided in the original print article). Fertility and Sterility 2011 95, 2439-2448.e5DOI: (10.1016/j.fertnstert.2011.05.070) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions