Antinociceptive role of 5-HT1A receptors in rat spinal cord

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Antinociceptive role of 5-HT1A receptors in rat spinal cord R. Nadeson, C.S. Goodchild British Journal of Anaesthesia Volume 88, Issue 5, Pages 679-684 (May 2002) DOI: 10.1093/bja/88.5.679 Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 1 Dose–response curves for the antinociceptive effects of the non-selective 5-HT1 agonist 1-(3-chlorophenyl)-piperazine dihydrochloride in the ECT and TFL tests. Intrathecal 1-(3-chlorophenyl)-piperazine dihydrochloride produced dose-related antinociception in both tests. ECT (neck) values did not increase after intrathecal injections of 1-(3-chlorophenyl)-piperazine dihydrochloride, indicating that the drug was confined in its actions to the caudal segments of the spinal cord responsible for tail innervation. Data points are means and bars are sem (n=4). British Journal of Anaesthesia 2002 88, 679-684DOI: (10.1093/bja/88.5.679) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 2 Dose–response curves for the antinociceptive effects of the selective 5-HT1A agonist 8-hydroxy-DPAT in the ECT and TFL tests. Intrathecal 8-hydroxy-DPAT caused dose-related antinociception in the ECT test only. TFL was not affected by intrathecal injections of 8-hydroxy-DPAT. ECT (neck) values did not increase after intrathecal injections of 8-hydroxy-DPAT, indicating that the drug was confined in its actions to the caudal segments of the spinal cord responsible for tail innervation. Data points are means and bars are sem (n=4–6). British Journal of Anaesthesia 2002 88, 679-684DOI: (10.1093/bja/88.5.679) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions

Fig 3 Dose–response curves for reversal of the antinociceptive effects of (a) 1-(3-chlorophenyl)-piperazine dihydrochloride (non-selective 5-HT1 agonist) and (b) 8-hydroxy-DPAT (selective 5-HT1A agonist) by the selective 5-HT1A antagonist 4-[3-(benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)-piperazine in the ECT and TFL tests. The antagonist suppressed the antinociceptive effects of both agonists in the ECT test in a dose-related manner. [Antinociception revealed by TFL after intrathecal injections of the non-selective 5-HT1 agonist 1-(3-chlorophenyl)-piperazine dihydrochloride was not affected by intrathecal injections of the antagonist 4-[3-(benzotriazol-1-yl)propyl]-1-(2-methoxyphenyl)-piperazine.] ECT (neck) values did not increase after intrathecal injections of either agonist in these experiments, indicating that the agonist drugs were confined in their actions to the caudal segments of the spinal cord responsible for tail innervation. Points shown are means and bars are sem (n=4–5). British Journal of Anaesthesia 2002 88, 679-684DOI: (10.1093/bja/88.5.679) Copyright © 2002 British Journal of Anaesthesia Terms and Conditions