Relationship between the Vertical Asymmetry of the Posterior Pole of the Eye and the Visual Field Damage in Glaucomatous Eyes  Kazunori Hirasawa, CO, PhD, Takehiro Yamashita, MD, PhD, Yuri Fujino, CO, Masato Matsuura, CO, Mieko Yanagisawa, CO, PhD, Yuya Kii, MD, Taiji Sakamoto, MD, PhD, Hiroshi Murata, MD, Ryo Asaoka, MD, PhD  Ophthalmology Glaucoma  Volume 2, Issue 1, Pages 28-35 (January 2019) DOI: 10.1016/j.ogla.2018.11.002 Copyright © 2018 American Academy of Ophthalmology Terms and Conditions

Figure 1 Sectors used for analysis. The visual field (VF) was divided into 3 areas: the central (dots), middle (oblique lines), and peripheral (grey) areas, based on the Garway-Heath map.13 The hemifield area (bold line) included all 3 areas. Four test points in the temporal area and 2 test points corresponding to the blind spots were excluded (not available). Ophthalmology Glaucoma 2019 2, 28-35DOI: (10.1016/j.ogla.2018.11.002) Copyright © 2018 American Academy of Ophthalmology Terms and Conditions

Figure 2 Calculation of the asymmetry of retinal tilt (RT) and posterior pole classification. All cross-sectional images were segmented using ReLayer.16 Red: the inner limiting membrane; green: between the retinal pigment epithelium (RPE) and photoreceptor inner/outer segment. A, The OCT image (vertical-to-horizontal [V:H] ratio = 1:1) was laterally expanded 4 times to easily recognize the RT as shown in the right image (V:H = 4:1). A line was drawn under the RPE parallel to the inner/outer segment line under the fovea. The magnitude of the superior or inferior RT was calculated as the difference between the lower margins of the RPE at the fovea and at locations 2.5 mm superior or inferior to the RPE. B, Classification of symmetry and asymmetry. C, Subclassification as the flat, dome, and convex types. The retinal images that had the same types of both inferior and superior regions were classified as symmetrical, whereas those with different types of inferior and superior regions were classified as asymmetrical. Subclassification of the superior and inferior regions was performed separately. Ophthalmology Glaucoma 2019 2, 28-35DOI: (10.1016/j.ogla.2018.11.002) Copyright © 2018 American Academy of Ophthalmology Terms and Conditions

Figure 3 Scatter plot of the relationship between the mean total deviation (mTD) and retinal tilt (RT) asymmetry. These scatter plots show the relationships between the vertical asymmetries of the mTD in the (A) hemifield, (B) central, (C) middle, (D) peripheral areas, and the RT vertical asymmetry. The hemifield, middle, and peripheral mTD asymmetries were significantly related to the RT asymmetry (P = 0.017, 0.029, and 0.023, respectively), but the central mTD asymmetry was not significantly related to the RT asymmetry (P = 0.40) and other variables (P > 0.05). cR2 = conditional R2; dB = decibels; mR2 = marginal R2. Ophthalmology Glaucoma 2019 2, 28-35DOI: (10.1016/j.ogla.2018.11.002) Copyright © 2018 American Academy of Ophthalmology Terms and Conditions