Mélanie Anne Hamon, Pascale Cossart Cell Host & Microbe

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Histone Modifications and Chromatin Remodeling during Bacterial Infections Mélanie Anne Hamon, Pascale Cossart Cell Host & Microbe Volume 4, Issue 2, Pages 100-109 (August 2008) DOI: 10.1016/j.chom.2008.07.009 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 Nucleosome Structure and Histone Tail Modifications (A) The arrangement of the eight histone proteins in the nucleosome is shown schematically. One hundred and forty-seven base pairs of DNA are wrapped around the histone core. Histone H1 seals the nucleosome separating each nucleosome unit from each other. (B) Covalent modifications of histone tails as listed per histone. The sequences of the N-terminal tails of histones are shown with amino acid position indicated in gray underneath. Modifications shown above the sequence are associated with an activation of transcription and those indicated beneath are associated with transcriptional repression. Cell Host & Microbe 2008 4, 100-109DOI: (10.1016/j.chom.2008.07.009) Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 2 Dual Role of Phosphorylated Serine 10 on Histone H3 in Transcription and in Mitosis During interphase, mitogenic signals (which include stress, growth factor, and developmental factor signals) activate MAPK signaling culminating in translocation of the MAPKs to the nucleus, where they activate a downstream kinase (MSK1 or MSK2) leading to phosphorylation of H3S10. This mark is thought to be a predisposing mark for acetylation and transcriptional activation. During mitosis, H3S10 becomes phosphorylated by specific mitotic kinases, leading to chromosomal condensation and proper cell division. Cell Host & Microbe 2008 4, 100-109DOI: (10.1016/j.chom.2008.07.009) Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 3 Schematic Representation of Mycobacterium-Induced Signaling as Described in the Text Cell Host & Microbe 2008 4, 100-109DOI: (10.1016/j.chom.2008.07.009) Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 4 Schematic Representation of Shigella, Listeria, and Helicobacter-Induced Signaling as Described in the Text Cell Host & Microbe 2008 4, 100-109DOI: (10.1016/j.chom.2008.07.009) Copyright © 2008 Elsevier Inc. Terms and Conditions