Role of periostin and discoidin domain receptor-1 (DDR1) in the regulation of cartilage degeneration and expression of MMP-13 M. Attur, Q. Yang, T. Kirsch,

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Role of periostin and discoidin domain receptor-1 (DDR1) in the regulation of cartilage degeneration and expression of MMP-13 M. Attur, Q. Yang, T. Kirsch, S.B. Abramson Osteoarthritis and Cartilage Volume 24, (April 2016) DOI: 10.1016/j.joca.2016.01.307 Copyright © 2016 Terms and Conditions

Figure 1. DDR1 inhibitor attenuates both constitutive and periostin-induced MMP-13 expression in human OA cartilage. MMP-13 levels in human cartilage explants treated as described in Methods. Means±SD of triplicate samples are shown. Statistical significance was determined by 1-way ANOVA with post-Bonferroni multiple comparison test. p<0.05, control vs. DDR1 inhibitor-treated; p<0.01, control vs. periostin + DDR1- inhibitor. Osteoarthritis and Cartilage 2016 24, DOI: (10.1016/j.joca.2016.01.307) Copyright © 2016 Terms and Conditions