Pulmonary autograft valve explants show typical degeneration

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Presentation transcript:

Pulmonary autograft valve explants show typical degeneration Aart Mookhoek, MSc, Emile de Heer, PhD, Ad J.J.C. Bogers, MD, PhD, Johanna J.M. Takkenberg, MD, PhD, Paul H. Schoof, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 139, Issue 6, Pages 1416-1419 (June 2010) DOI: 10.1016/j.jtcvs.2010.01.020 Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Morphologic analysis shows a thickened autograft (Au) ventricularis compared with that seen in normal aortic (Ao) and pulmonary (P) valves (upper mid panel, original magnification 135×). Detailed photos of the autograft valves show cubical endothelium (lower left, V), collagen-rich extracellular matrix (lower mid), and high density of spindle-shaped cells (lower right; original magnification, 540×). The Journal of Thoracic and Cardiovascular Surgery 2010 139, 1416-1419DOI: (10.1016/j.jtcvs.2010.01.020) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Confocal images of valvular collagen structures show an increase in collagen density in pulmonary autograft valves (lower left) compared with that seen in normal aortic and pulmonary valves (upper panels; original magnification, 800×). Distinct radial orientation of the collagen fibers is shown at high magnification (lower right; original magnification, 1600×). V, Ventricularis. The Journal of Thoracic and Cardiovascular Surgery 2010 139, 1416-1419DOI: (10.1016/j.jtcvs.2010.01.020) Copyright © 2010 The American Association for Thoracic Surgery Terms and Conditions