Masahiko Kanamori, Cristina R. Antonescu, Melody Scott, Robert S

Slides:

Advertisements

Similar presentations

Measurement of Relative Copy Number of CDKN2A/ARF and CDKN2B in Bladder Cancer by Real-Time Quantitative PCR and Multiplex Ligation-Dependent Probe Amplification.

Advertisements

Development of a Novel One-Tube Isothermal Reverse Transcription Thermophilic Helicase-Dependent Amplification Platform for Rapid RNA Detection James Goldmeyer,

CyclinD1/CyclinD3 Ratio by Real-Time PCR Improves Specificity for the Diagnosis of Mantle Cell Lymphoma Carol D. Jones, Katherine H. Darnell, Roger A.

Quantification of Parvovirus B19 DNA Using COBAS AmpliPrep Automated Sample Preparation and LightCycler Real-Time PCR Stefan Schorling, Gunnar Schalasta,

Design and Multiseries Validation of a Web-Based Gene Expression Assay for Predicting Breast Cancer Recurrence and Patient Survival Ryan K. Van Laar The.

Kazunori Kanehira, Douglas L. Riegert-Johnson, Dong Chen, Lawrence E

Intratumoral Patterns of Clonal Evolution in Meningiomas as Defined by Multicolor Interphase Fluorescence in Situ Hybridization (FISH) José María Sayagués,

Droplet Digital PCR for Absolute Quantification of EML4-ALK Gene Rearrangement in Lung Adenocarcinoma Qiushi Wang, Xin Yang, Yong He, Qiang Ma, Li Lin,

Tracy I. George, Joanna E. Wrede, Charles D. Bangs, Athena M

Molecular Diagnosis of Clear Cell Sarcoma

The 2015 World Health Organization Classification of Tumors of the Pleura: Advances since the 2004 Classification Francoise Galateau-Salle, MD, Andrew.

Microarray-Based Comparative Genomic Hybridization Using Sex-Matched Reference DNA Provides Greater Sensitivity for Detection of Sex Chromosome Imbalances.

Laboratory Guidelines for Detection, Interpretation, and Reporting of Maternal Cell Contamination in Prenatal Analyses Narasimhan Nagan, Nicole E. Faulkner,

TERT and AURKA Gene Copy Number Gains Enhance the Detection of Acral Lentiginous Melanomas by Fluorescence in Situ Hybridization Alba Diaz, Joan Anton.

Quantitative Fluorescence in Situ Hybridization and its Ability to Predict Bladder Cancer Recurrence and Progression to Muscle-Invasive Bladder Cancer

Mutation Screening in Juvenile Polyposis Syndrome

Joanna Wang, Chetan Bettegowda The Journal of Molecular Diagnostics

FISH Analysis for the Detection of Lymphoma-Associated Chromosomal Abnormalities in Routine Paraffin-Embedded Tissue Roland A. Ventura, Jose I. Martin-Subero,

Jennelle C. Hodge, Patrick P. Bedroske, Kathryn E. Pearce, William R

Abnormal Villous Morphology Associated with Triple Trisomy of Paternal Origin Alexis Norris-Kirby, Jill M. Hagenkord, Malti P. Kshirsagar, Brigitte M.

Sarah Chiang, Ladan Fazlollahi, Anhthu Nguyen, Rebecca A

Kazunori Kanehira, Douglas L. Riegert-Johnson, Dong Chen, Lawrence E

Comparative Genomic Hybridization Analysis of Astrocytomas

Undifferentiated Small Round Cell Sarcomas with Rare EWS Gene Fusions

Customized Oligonucleotide Array-Based Comparative Genomic Hybridization as a Clinical Assay for Genomic Profiling of Chronic Lymphocytic Leukemia Rachel.

Sequencing of t(2;7) Translocations Reveals a Consistent Breakpoint Linking CDK6 to the IGK Locus in Indolent B-Cell Neoplasia Edward P.K. Parker, Reiner.

Mucinous Differentiation Correlates with Absence of EGFR Mutation and Presence of KRAS Mutation in Lung Adenocarcinomas with Bronchioloalveolar Features

The Development of a Multitarget, Multicolor Fluorescence in Situ Hybridization Assay for the Detection of Urothelial Carcinoma in Urine Irina A. Sokolova,

Detection of TERC Amplification in Cervical Epithelial Cells for the Diagnosis of High- Grade Cervical Lesions and Invasive Cancer Jing Jiang, Li-Hui.

Detecting 22q11.2 Deletions by Use of Multiplex Ligation-Dependent Probe Amplification on DNA from Neonatal Dried Blood Spot Samples Karina M. Sørensen,

343. Benchtop DNA Synthesizer: Oligo-Templated Polymerization (OTP)

Patrick R. Murray The Journal of Molecular Diagnostics

William L. Gerald, M.D., Ph.D, 1954–2008

PCR Analysis of the Immunoglobulin Heavy Chain Gene in Polyclonal Processes Can Yield Pseudoclonal Bands as an Artifact of Low B Cell Number Kojo S.J.

A Comparative Study of Fibrous Dysplasia and Osteofibrous Dysplasia with Regard to GSα Mutation at the Arg201 Codon Akio Sakamoto, Yoshinao Oda, Yukihide.

Identification of Combinatorial Genomic Abnormalities Associated with Prostate Cancer Early Recurrence Xiaoyu Qu, Claudio Jeldres, Lena Glaskova, Cynthia.

Hepatosplenic and Subcutaneous Panniculitis-Like γ/δ T Cell Lymphomas Are Derived from Different Vδ Subsets of γ/δ T Lymphocytes Grzegorz K. Przybylski,

Intratumoral Patterns of Clonal Evolution in Meningiomas as Defined by Multicolor Interphase Fluorescence in Situ Hybridization (FISH) José María Sayagués,

The Human Androgen Receptor X-Chromosome Inactivation Assay for Clonality Diagnostics of Natural Killer Cell Proliferations Michaël Boudewijns, Jacques.

Development of an NPM1/MLF1 D-FISH Probe Set for the Detection of t(3;5)(q25;q35) Identified in Patients with Acute Myeloid Leukemia Umut Aypar, Ryan.

Chromosomal Biomarkers for Detection of Human Papillomavirus Associated Genomic Instability in Epithelial Cells of Cervical Cytology Specimens Irina.

Cyclin E1 Is Amplified and Overexpressed in Osteosarcoma

Delineation of HER2 Gene Status in Breast Carcinoma by Silver in Situ Hybridization is Reproducible among Laboratories and Pathologists Antonino Carbone,

Raymond R. Tubbs, James Pettay, Pat Roche, Mark H

Inconspicuous Insertion 22;12 in Myxoid/Round Cell Liposarcoma Accompanied by the Secondary Structural Abnormality der(16)t(1;16) Nathan C. Birch, Cristina.

Diagnosis of BK Viral Nephropathy in the Renal Allograft Biopsy

The MECT1-MAML2 Gene Fusion and Benign Warthin's Tumor

The Genetics of Cellular Senescence

A Practical Approach to the Detection of Prognostically Significant Genomic Aberrations in Multiple Myeloma Zhong Chen, Bonnie Issa, Shiang Huang, Emily.

The Molecular Pathology of Primary Immunodeficiencies

Severe Chromosomal Aberrations in Pleural Mesotheliomas with Unusual Mesodermal Features Michael Krismann, Klaus-Michael Müller, Malgorzata Jaworska,

Chromosomal Abnormalities in Non-Small Cell Lung Carcinomas and in Bronchial Epithelia of High-Risk Smokers Detected by Multi-Target Interphase Fluorescence.

Daynna J. Wolff, Adam Bagg, Linda D. Cooley, Gordon W. Dewald, Betsy A

Kathleen M. Murphy, Julie S. Cohen, Amy Goodrich, Patricia P

Defining Ploidy-Specific Thresholds in Array Comparative Genomic Hybridization to Improve the Sensitivity of Detection of Single Copy Alterations in Cell.

Molecular Cytogenetic Analyses of Immunoglobulin Loci in Nodular Lymphocyte Predominant Hodgkin's Lymphoma Reveal a Recurrent IGH-BCL6 Juxtaposition

Successful Application of a Direct Detection Slide-Based Sequential Phenotype/Genotype Assay Using Archived Bone Marrow Smears and Paraffin Embedded.

Array Comparative Genomic Hybridization Detects Chromosomal Abnormalities in Hematological Cancers That Are Not Detected by Conventional Cytogenetics

The Detection of t(14;18) in Archival Lymph Nodes

Long Polymerase Chain Reaction-Based Fluorescence in Situ Hybridization Analysis of Female Carriers of X-Linked Chronic Granulomatous Disease Deletions

Amplification and Overexpression of the EMS 1 Oncogene, a Possible Prognostic Marker, in Human Hepatocellular Carcinoma Bao-Zhu Yuan, Xiaoling Zhou,

Development of Five Dual-Color, Double-Fusion Fluorescence in Situ Hybridization Assays for the Detection of Common MLL Translocation Partners Jeannette.

Katy Hanlon, Lorna W. Harries, Sian Ellard, Claudius E. Rudin

Diagnosis of BK Viral Nephropathy in the Renal Allograft Biopsy

Karen Snow-Bailey, Ph.D., 1961–2006

Telomeric IGH Losses Detectable by Fluorescence in Situ Hybridization in Chronic Lymphocytic Leukemia Reflect Somatic VH Recombination Events Iwona Wlodarska,

Jie Hu, Malini Sathanoori, Sally J. Kochmar, Urvashi Surti

Genetic Characterization of a Human Skin Carcinoma Progression Model: from Primary Tumor to Metastasis Susanne Popp, Stefan Waltering, Petra Boukamp

Angiotensin I-Converting Enzyme

Monique A. Johnson, Marvin J. Yoshitomi, C. Sue Richards

Presentation transcript:

Extra Copies of Chromosomes 7, 8, 12, 19, and 21 are Recurrent in Adamantinoma Masahiko Kanamori, Cristina R. Antonescu, Melody Scott, Robert S. Bridge, James R. Neff, Suzanne S. Spanier, Mark T. Scarborough, Gerardo Vergara, Howard G. Rosenthal, Julia A. Bridge The Journal of Molecular Diagnostics Volume 3, Issue 1, Pages 16-21 (February 2001) DOI: 10.1016/S1525-1578(10)60644-7 Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 1 The Case 2 lesion involving the anterior cortex has multiple radiolucent defects surrounded by areas of cortical thickening and a thick rim of reactive bone at the base. One can observe indolent progression of the radiolucent areas from the first film taken July, 1995 (left) to subsequent ones obtained May, 1996 (center) and December, 1999 (right). The Journal of Molecular Diagnostics 2001 3, 16-21DOI: (10.1016/S1525-1578(10)60644-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 2 A: The medullary side of a portion of the reactive cortex is at the top of the left hand corner. It is fairly mature, but lacks well-developed Harversian systems and stress lines. Connected to it and protruding toward the underlying lesion, are thickened trabeculae of irregular, immature bone variably rimmed by osteoblasts. Osteoclastic remodeling can be seen in the lower right hand corner. B:The center of the lesion is characterized by a bland proliferation of cells having spindle shaped, often slender, nuclei arranged in a loose storiform pattern. Embedded within this stroma are two nests of epithelial cells. C: An immunohistochemical preparation for cytokeratins highlights three nests of epithelial cells. In addition, multiple keratin reactive single cells within the stroma, not otherwise detectable, can be appreciated. The Journal of Molecular Diagnostics 2001 3, 16-21DOI: (10.1016/S1525-1578(10)60644-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 3 GTG-banded karyotype of Case 1: 54, XX,−1,+5,+der(7)t(?1;7)(?q21;q22),+der(8)t(1;8)(q21;q24.3),+der(q)t(1:9)(p32;q34),+19,+20,+ 21,+mar1,+mar2. The Journal of Molecular Diagnostics 2001 3, 16-21DOI: (10.1016/S1525-1578(10)60644-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 4 GTG-banded karyotype of the primary clone in Case 2: 54, XY,+5,+7,+8,+12,+12,+14,+19,+21. The Journal of Molecular Diagnostics 2001 3, 16-21DOI: (10.1016/S1525-1578(10)60644-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions

Figure 5 A: FISH analysis performed on cytologic touch preparations of Case 3 revealed three hybridization signals for chromosome 8 (red) and two hybridization signals for chromosome 12 (green). B:FISH analysis performed on cytologic touch preparations of Case 3 revealed three hybridization signals for chromosome 19. C:FISH analysis performed on cytologic touch preparations of Case 4 revealed five to eight hybridization signals for chromosome 8 (red) and four hybridization signals for chromosome 12 (green). The Journal of Molecular Diagnostics 2001 3, 16-21DOI: (10.1016/S1525-1578(10)60644-7) Copyright © 2001 American Society for Investigative Pathology and Association for Molecular Pathology Terms and Conditions