Intrapleural administration of gelatin-embedded, sustained-release basic fibroblast growth factor for the regeneration of emphysematous lungs in rats

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Presentation transcript:

Intrapleural administration of gelatin-embedded, sustained-release basic fibroblast growth factor for the regeneration of emphysematous lungs in rats Mitsumasa Kawago, MD, Tatsuya Yoshimasu, MD, PhD, Yasuhiko Tabata, PhD, DMedSci, DPharm, Masaya Yamamoto, PhD, Yoshimitsu Hirai, MD, PhD, Takahiro Kinoshita, MD, PhD, Yoshitaka Okamura, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 147, Issue 5, Pages 1644-1649 (May 2014) DOI: 10.1016/j.jtcvs.2013.07.039 Copyright © 2014 Terms and Conditions

Figure 1 Microscopic findings of lung sections. A, Normal lung (untreated group). The mean linear intercept of this section was 57.7 μm. B, Ten weeks after administration of porcine elastase (elastase-only group). The mean linear intercept of this section was 121.7 μm. Hematoxylin and eosin staining, ×100. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1644-1649DOI: (10.1016/j.jtcvs.2013.07.039) Copyright © 2014 Terms and Conditions

Figure 2 Representative microscopic findings of the lung sections of rats who received gelatin hydrogel particles. A, Right lung in the fibroblast growth factor (FGF)− group. B, Left lung in the FGF− group. C, Right lung in the FGF+ group. D, Left lung in the FGF+ group. Hematoxylin and eosin staining, ×100. The mean linear intercepts in these sections were 109.2 μm in A, 122.7 μm in B, 109.9 μm in C, and 67.1 μm in D. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1644-1649DOI: (10.1016/j.jtcvs.2013.07.039) Copyright © 2014 Terms and Conditions

Figure 3 Mean linear intercepts of the lung sections of rats that received gelatin hydrogel particles. b-FGF, Basic fibroblast growth factor. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1644-1649DOI: (10.1016/j.jtcvs.2013.07.039) Copyright © 2014 Terms and Conditions

Figure 4 Microscopic findings of lung sections of the right lung (A) and left lung (B) in the same rat at low magnification (×20). Left side of the photo is the subpleural region and right side is the center of the lung. Lung regeneration appeared to occur in the center of the lung and the subpleural area. The Journal of Thoracic and Cardiovascular Surgery 2014 147, 1644-1649DOI: (10.1016/j.jtcvs.2013.07.039) Copyright © 2014 Terms and Conditions