Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig M. Zaar, N.H. Secher, P.I. Johansson, B. Vainer,

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Effects of a recombinant FVIIa analogue, NN1731, on blood loss and survival after liver trauma in the pig M. Zaar, N.H. Secher, P.I. Johansson, B. Vainer, M. Ezban, H. Agersø, P.L. Madsen, N. Lomholt, M.B. Hermit, B. Lauritzen British Journal of Anaesthesia Volume 103, Issue 6, Pages 840-847 (December 2009) DOI: 10.1093/bja/aep274 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 1 Blood loss (a) and Kaplan–Meier survival plot (b) for pigs after a grade IV liver trauma and i.v. administration of NN1731 180 µg kg−1 [n=6; 36 (1) kg], i.m. administration of 540 [n=4; 33 (1) kg] or 2000 µg kg−1 [n=6; 35 (1) kg], or control [n=16; 33 (1) kg]. I.V. administration of NN1731 and initiation of fluid administration were 7 min after the trauma, while i.m. administration of NN1731 was 1 min after the trauma. Dashed lines (a) beginning of the different fluid administration phases: P1, 0.7 ml kg−1 min−1; P2, 1.65 ml kg−1 min−1; and P3, according to blood loss (ratio 1:1). Fluid administered was with lactated Ringer in P1–2 and HES 130/0.4 in P3. Data for P3 are normalized to experimentation time and presented as mean (sd). **Different from the control group (P<0.01). British Journal of Anaesthesia 2009 103, 840-847DOI: (10.1093/bja/aep274) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 2 MAP, CVP, HR, CO, and oxygen delivery (DO2) and uptake (VO2) for pigs after a grade IV liver trauma and i.v. administration of NN1731 180 µg kg−1 [n=6; 36 (1) kg], i.m. administration of 540 [n=4; 33 (1) kg] or 2000 µg kg−1 [n=6; 35 (1) kg] or control [n=16; 33 (1) kg]. For details see legend to Figure 1. British Journal of Anaesthesia 2009 103, 840-847DOI: (10.1093/bja/aep274) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

Fig 3 FVIIa-like clot activity for pigs (3–4 months of age) after a grade IV liver trauma and i.v. administration of NN1731 180 µg kg−1 [n=6; 36 (1) kg] or i.m. administration of 540 [n=4; 33 (1) kg] or 2000 µg kg−1 [n=6; 35 (1) kg]. For details see legend to Figure 1. British Journal of Anaesthesia 2009 103, 840-847DOI: (10.1093/bja/aep274) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions