Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium Akihisa Takasaki,

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Presentation transcript:

Endometrial growth and uterine blood flow: a pilot study for improving endometrial thickness in the patients with a thin endometrium Akihisa Takasaki, M.D., Ph.D., Hiroshi Tamura, M.D., Ph.D., Ichiro Miwa, M.D., Toshiaki Taketani, M.D., Ph.D., Katsunori Shimamura, M.D., Ph.D., Norihiro Sugino, M.D., Ph.D. Fertility and Sterility Volume 93, Issue 6, Pages 1851-1858 (April 2010) DOI: 10.1016/j.fertnstert.2008.12.062 Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Correlation between blood flow impedance of uterine radial arteries and endometrial thickness. (A) Correlation between uterine RA-RI and endometrial thickness (n = 66). (B) ROC curve analysis. RA-RI and endometrial thickness were measured for infertility patients in the late follicular phase (1–2 days before ovulation). Endometrial thickness was significantly and negatively correlated with RA-RI (single regression analysis). ROC curve analysis was performed to determine the cutoff value of the RA-RI providing the best values of sensitivity and specificity for determination of normal and thin endometrium. The cutoff value of 0.81 provided the best combination, with 89.3% sensitivity and 87.6% specificity to discriminate between normal and thin endometrium. Fertility and Sterility 2010 93, 1851-1858DOI: (10.1016/j.fertnstert.2008.12.062) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Effects of vitamin E treatment on VEGF expression in the endometrium of the patients with a thin endometrium. Vitamin E (600 mg/day) was given to five patients with a thin endometrium (endometrial thickness <8 mm) and high RA-RI (≥0.81) throughout the menstrual cycle, and endometrial biopsy specimens were obtained in the midluteal phase before and during vitamin E treatment. VEGF expression was analyzed by Western blotting. Representative immunoblots of VEGF protein expression before [vit E (−)] and during [vit E (+)] vitamin E treatment are shown from three patients. The right panel shows the quantification of immunoblot signals (ratio of VEGF to β-tubulin), mean + SEM. ∗P<.05 vs. vit E (−) (Mann-Whitney U-test). Fertility and Sterility 2010 93, 1851-1858DOI: (10.1016/j.fertnstert.2008.12.062) Copyright © 2010 American Society for Reproductive Medicine Terms and Conditions