Phagocytosis: An Immunobiologic Process Siamon Gordon  Immunity  Volume 44, Issue 3, Pages 463-475 (March 2016) DOI: 10.1016/j.immuni.2016.02.026 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 The Phagocytic Pathway Uptake of exogenous particles (heterophagy) results in a dynamic, integrated sequence of plasma-membrane fusion and fission with intracellular vesicular membranes, maturation of phagosomes, and progressive acidification, culminating in phagolysosomal fusion and digestion. This pathway intersects with biosynthetic and secretory pathways. Adapted from Russell (2011) with permission. Immunity 2016 44, 463-475DOI: (10.1016/j.immuni.2016.02.026) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Plasma-Membrane Receptors that Mediate Phagocytic Recognition of Microbes and/or Apoptotic Cells Prepared by A. Plüddemann. Immunity 2016 44, 463-475DOI: (10.1016/j.immuni.2016.02.026) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 3 The Phagocytic Synapse: Role of Dectin-1, FcR, and Integrins Schematic representation of Dectin-1 clustering at the site of contact with particulate zymosan; CD45 and CD148 tyrosine phosphatases are excluded from the contact zone (reproduced from Goodridge et al., 2011, with permission). Integrins and their ligands form an expanding actin-based diffusion barrier that facilitates receptor engagement and coordinates CD45 depletion during FcR-mediated phagocytosis. Activation by multiple integrin ligands enables bridging of sparse phagocytic receptors (Freeman et al., 2016). Immunity 2016 44, 463-475DOI: (10.1016/j.immuni.2016.02.026) Copyright © 2016 Elsevier Inc. Terms and Conditions