Variable versus conventional lung protective mechanical ventilation during open abdominal surgery (PROVAR): a randomised controlled trial P.M. Spieth,

Slides:

Advertisements

Similar presentations

Radiofrequency Ablation vs Conventional Surgery for Varicose Veins – a Comparison of Treatment Costs in a Randomised Trial S. Subramonia, T. Lees European.

Advertisements

Chewing gum for the treatment of postoperative nausea and vomiting: a pilot randomized controlled trial J.N. Darvall, M Handscombe, K Leslie British.

Effects of staff training on the care of mechanically ventilated patients: a prospective cohort study F. Bloos, S. Müller, A. Harz, M. Gugel, D. Geil,

Randomized controlled trial comparing the McGrath videolaryngoscope with the C-MAC videolaryngoscope in intubating adult patients with potential difficult.

Ventilation with low tidal volumes during upper abdominal surgery does not improve postoperative lung function T.A. Treschan, W. Kaisers, M.S. Schaefer,

C. Unzueta, G. Tusman, F. Suarez-Sipmann, S. Böhm, V. Moral

Randomized controlled trial of stroke volume optimization during elective major abdominal surgery in patients stratified by aerobic fitness C.W. Lai,

Propofol compared with sevoflurane general anaesthesia is associated with decreased delayed neurocognitive recovery in older adults Y. Zhang, G.-J. Shan,

Efficacy and adverse effects of buprenorphine in acute pain management: systematic review and meta-analysis of randomised controlled trials L.D. White,

Why is the surgical high-risk patient still at risk?

Bispectral index-guided induction of general anaesthesia in patients undergoing major abdominal surgery using propofol or etomidate: a double-blind, randomized,

Xenon anaesthesia for patients undergoing off-pump coronary artery bypass graft surgery: a prospective randomized controlled pilot trial† L. Al tmimi,

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

International normalized ratio and prothrombin time values before the removal of a lumbar plexus catheter in patients receiving warfarin after total hip.

K.-Y. Ho, W Tay, M.-C. Yeo, H Liu, S.-J. Yeo, S.-L. Chia, N.-N. Lo

Effect of combining tramadol and morphine in adult surgical patients: a systematic review and meta-analysis of randomized trials V. Martinez, L. Guichard,

Cost-effectiveness of a systematic e-assessed follow-up of postoperative recovery after day surgery: a multicentre randomized trial K. Dahlberg, A. Philipsson,

I.I. Siempos, K.Z. Vardakas, M.E. Falagas

Paracetamol and selective and non-selective non-steroidal anti-inflammatory drugs for the reduction in morphine-related side-effects after major surgery:

Could patient-controlled thirst-driven fluid administration lead to more rapid rehydration than clinician-directed fluid management? An early feasibility.

Efficacy of perioperative dexmedetomidine on postoperative delirium: systematic review and meta-analysis with trial sequential analysis of randomised.

Differential effects of lidocaine and remifentanil on response to the tracheal tube during emergence from general anaesthesia J.H. Lee, B.-N. Koo, J.-J.

Randomized controlled trial of goal-directed haemodynamic treatment in patients with proximal femoral fracture E. Bartha, C. Arfwedson, A. Imnell, M.E.

Postoperative pulmonary complications

Randomised trial comparing forced-air warming to the upper or lower body to prevent hypothermia during thoracoscopic surgery in the lateral decubitus.

A. Duma, C. Wagner, M. Titz, M. Maleczek, M. Hüpfl, V. B. Weihs, E

M.A. Olympio, R. Whelan, R.P.A. Ford, I.C.M. Saunders

Pain after orthopaedic surgery: differences in patient reported outcomes in the United States vs internationally. An observational study from the PAIN.

Measuring non-technical skills of anaesthesiologists in the operating room: a systematic review of assessment tools and their measurement properties

Single-dose aprepitant vs ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients.

Iontophoretic transdermal system using fentanyl compared with patient-controlled intravenous analgesia using morphine for postoperative pain management†

M. O'Hare, Y. Maldonado, J. Munro, M. J. Ackerman, H. Ramakrishna, D

K.J. Chin British Journal of Anaesthesia

I.V. paracetamol as an adjunct to patient-controlled epidural analgesia with levobupivacaine and fentanyl in labour: a randomized controlled study K.

Postoperative pulmonary complications, pulmonary and systemic inflammatory responses after lung resection surgery with prolonged one-lung ventilation.

Introduction of a paediatric anaesthesia comic information leaflet reduced preoperative anxiety in children B. Kassai, M. Rabilloud, E. Dantony, S. Grousson,

Comparison of the effects of xenon and sevoflurane anaesthesia on leucocyte function in surgical patients: a randomized trial† A.V. Fahlenkamp, M. Coburn,

Anaesthesia for awake craniotomy—evolution of a technique that facilitates awake neurological testing A. Sarang, J. Dinsmore British Journal of Anaesthesia

Uvula necrosis after fibreoptic intubation

Effects of tracheal tube orientation on the success of intubation through an intubating laryngeal mask airway: study in Mallampati class 3 or 4 patients

Lung recruitment and positive airway pressure before extubation does not improve oxygenation in the post-anaesthesia care unit: a randomized clinical.

Incidence, characteristics, and predictive factors for medication errors in paediatric anaesthesia: a prospective incident monitoring study C. Gariel,

Β2-Adrenoceptor gene variants affect vasopressor requirements in patients after thoracic epidural anaesthesia U.H. Frey, J. Karlik, F. Herbstreit, J.

Spinal analgesia for laparoscopic colonic resection using an enhanced recovery after surgery programme: better analgesia, but no benefits on postoperative.

P. Persson, O. Stenqvist, S. Lundin British Journal of Anaesthesia

GlideScope® video laryngoscope: a randomized clinical trial in 203 paediatric patients† J.-T. Kim, H.-S. Na, J.-Y. Bae, D.-W. Kim, H.-S. Kim, C.S. Kim,

N. Curry, C. Rourke, R. Davenport, S. Beer, L. Pankhurst, A. Deary, H

Effect of supervised aerobic exercise rehabilitation on physical fitness and quality-of-life in survivors of critical illness: an exploratory minimized.

The association between obesity and disability in survivors of joint surgery: analysis of the health and retirement study T.G. Gaulton, L.A. Fleisher,

Do simple ventilation and gas exchange measurements predict early successful weaning from respiratory support in unselected general intensive care patients?

Thoracic paravertebral blocks in abdominal surgery – a systematic review of randomized controlled trials K. El-Boghdadly, C. Madjdpour, K.J. Chin British.

Chewing gum for the treatment of postoperative nausea and vomiting: a pilot randomized controlled trial J.N. Darvall, M Handscombe, K Leslie British.

Oral vs intravenous paracetamol for lower third molar extractions under general anaesthesia: is oral administration inferior? S. Fenlon, J. Collyer,

T. Mizota, Y. Yamamoto, M. Hamada, S. Matsukawa, S. Shimizu, S. Kai

J.E. Spiegel, A. Vasudevan, Y. Li, P.E. Hess

Stress response during weaning after cardiac surgery

Effect of early tracheostomy on resource utilization and clinical outcomes in critically ill patients: meta-analysis of randomized controlled trials

Feasibility and safety of xenon compared with sevoflurane anaesthesia in coronary surgical patients: a randomized controlled pilot study† C Stoppe,

Sodium bicarbonate does not prevent postoperative acute kidney injury after off-pump coronary revascularization: a double-blinded randomized controlled.

Comparison of economical aspects of interscalene brachial plexus blockade and general anaesthesia for arthroscopic shoulder surgery C. Gonano, S.C. Kettner,

Systematic review of the QoR-15 score, a patient- reported outcome measure measuring quality of recovery after surgery and anaesthesia J. Kleif, J. Waage,

Controlled hypotension for middle ear surgery: a comparison between remifentanil and magnesium sulphate† J.-H. Ryu, I.-S. Sohn, S.-H. Do British Journal.

Effect of preoxygenation using non-invasive ventilation before intubation on subsequent organ failures in hypoxaemic patients: a randomised clinical trial

Additional femoral catheter in combination with popliteal catheter for analgesia after major ankle surgery S Blumenthal, A Borgeat, C Neudörfer, R Bertolini,

Influence of head and neck position on ventilation using the air-Q® SP airway in anaesthetized paralysed patients: a prospective randomized crossover.

M. J. Sheen, S. -T. Ho, C. -H. Lee, Y. -C. Tsung, F. -L. Chang, S. -T

The Propranolol Aneurysm Trial Investigators

F. Neunhoeffer, T. Wahl, M. Hofbeck, H. Renk, M. Esslinger, M

K. Ruetzler, G. Grubhofer, W. Schmid, D. Papp, S. Nabecker, D

M.S. Schaefer, T.A. Treschan, J. Gauch, M. Neukirchen, P. Kienbaum

Presentation transcript:

Variable versus conventional lung protective mechanical ventilation during open abdominal surgery (PROVAR): a randomised controlled trial P.M. Spieth, A. Güldner, C. Uhlig, T. Bluth, T. Kiss, C. Conrad, K. Bischlager, A. Braune, R. Huhle, A. Insorsi, F. Tarantino, L. Ball, M.J. Schultz, N. Abolmaali, T. Koch, P. Pelosi, M. Gama de Abreu British Journal of Anaesthesia Volume 120, Issue 3, Pages 581-591 (March 2018) DOI: 10.1016/j.bja.2017.11.078 Copyright © 2017 British Journal of Anaesthesia Terms and Conditions

Fig 1 CONSORT Diagram. Patient flow in the PROtective VARiable ventilation (PROVAR) study according to the CONSORT guidelines. 188 patients were screened for eligibility and 50 were finally enrolled in the trial. 25 patients were randomly assigned to receive either controlled variable ventilation or controlled non-variable ventilation, respectively. One patient in CVV and CNV groups refused being submitted to further measurements after days 1 and 3, respectively. One patient in CNV group was still intubated at day 1, so that the primary endpoint could not be assessed. Therefore intention to treat (ITT) analysis was performed in 24 patients in CVV and 23 patients in CNV group, respectively. British Journal of Anaesthesia 2018 120, 581-591DOI: (10.1016/j.bja.2017.11.078) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions

Fig 2 Forced vital capacity as percent of expected normal value. Closed circles represent controlled non-variable ventilation (CNV), whereas open circles represent controlled variable ventilation (CVV). Red lines represent mean and standard deviation. General linear model statistics were used to assess group, time and group∗time effects. A P < 0.05 was considered statistically significant. British Journal of Anaesthesia 2018 120, 581-591DOI: (10.1016/j.bja.2017.11.078) Copyright © 2017 British Journal of Anaesthesia Terms and Conditions