The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis Ms L. Torres, B.A., Dr D.D. Dunlop, Ph.D., Dr.

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Presentation transcript:

The relationship between specific tissue lesions and pain severity in persons with knee osteoarthritis Ms L. Torres, B.A., Dr D.D. Dunlop, Ph.D., Dr C. Peterfy, M.D., Ph.D., Dr A. Guermazi, M.D., Dr P. Prasad, Ph.D., Dr K.W. Hayes, Ph.D., Ms J. Song, M.S., Ms S. Cahue, M.P.H., Ms A. Chang, P.T., M.S., Ms M. Marshall, B.A., Dr L. Sharma, M.D. Osteoarthritis and Cartilage Volume 14, Issue 10, Pages 1033-1040 (October 2006) DOI: 10.1016/j.joca.2006.03.015 Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 The nociceptive pathway [adapted from figure by Kidd7]. Osteoarthritis and Cartilage 2006 14, 1033-1040DOI: (10.1016/j.joca.2006.03.015) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Median knee pain severity (mm, visual analogue scale) by MRI-based tissue lesion score quartiles for bone lesions, cartilage morphology, and meniscal tears. In this figure, median knee pain severity (in mm by visual analogue scale) is given for each quartile of lesion score. Higher lesion scores represent more severe pathology. The quartile cut-offs were: for bone attrition, 0, ≤2, ≤4, and >4; for bone marrow lesions, 0, ≤2, ≤4, and >4; for bone cysts, 0, ≤1, ≤2, and >2; for osteophytes, ≤7.50, ≤14, ≤21, and >21; for cartilage morphology, ≤7.25, ≤17, ≤23, and >23; and for meniscal tears, 0, ≤1, ≤4, and >4. Osteoarthritis and Cartilage 2006 14, 1033-1040DOI: (10.1016/j.joca.2006.03.015) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Median knee pain severity (mm, visual analogue scale) by MRI-based tissue lesion score for meniscal subluxation, ligament lesions, and synovitis/effusion. In this figure, median knee pain severity (in mm by visual analogue scale) is depicted for knees with the given tissue lesion score. Higher lesion scores represent more severe pathology. Osteoarthritis and Cartilage 2006 14, 1033-1040DOI: (10.1016/j.joca.2006.03.015) Copyright © 2006 OsteoArthritis Research Society International Terms and Conditions