Fig. 2. SSFO or SwiChR++ modulation of mPFC neurons and rescue of social behavior deficits in CNTNAP2 KO mice. SSFO or SwiChR++ modulation of mPFC neurons.

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Fig. 2. SSFO or SwiChR++ modulation of mPFC neurons and rescue of social behavior deficits in CNTNAP2 KO mice. SSFO or SwiChR++ modulation of mPFC neurons and rescue of social behavior deficits in CNTNAP2 KO mice. (A) Testing of social interaction behavior for 10 min in mouse pairs matched by genotype and sex is shown. A single 2-s, 473-nm pulse of blue light was administered immediately before the behavioral test in the stimulation condition. (B) The duration of social explorations during the first 10 interaction bouts with or without SSFO stimulation is shown (WTbaseline versus KObaseline, P < 0.05; KObaseline versus KOstimulation, P < 0.0001) (table S5). In (B) to (J), two-way ANOVA was used, followed by Dunnett’s pairwise comparisons; parameter interaction values and n values (at least eight pairs per condition) for each arm are shown in the Supplementary Materials. (C) Duration of social explorations during the total 10 min of the test with and without SSFO stimulation (WTbaseline versus KObaseline, P < 0.05; KObaseline versus KOstimulation, P < 0.05) (table S6). (D) Mean social exploration duration per interaction bout with and without SSFO stimulation (WTbaseline versus KObaseline, P < 0.05; KObaseline versus KOstimulation, P < 0.01) (table S7). (E) Mean social approach velocity with and without SSFO stimulation (WTbaseline versus KObaseline, P < 0.001; KObaseline versus KOstimulation, P < 0.05) (table S8). (F) Social interaction test after a 1-s intermittent 473-nm pulse of blue light to stimulate the inhibitory channelrhodopsin SwiChR++. (G) Social exploration duration during the first 10 interaction bouts with and without inhibitory SwiChR++ stimulation (WTstimulation versus KObaseline, P < 0.01; KObaseline versus KOstimulation, P < 0.05) (table S9). (H) Social exploration duration during the total length of the test (10 min) with and without inhibitory SwiChR++ stimulation (WTbaseline versus KObaseline, P < 0.05; KObaseline versus KOstimulation, P < 0.05) (table S10). (I) Mean social exploration duration per interaction bout with and without inhibitory SwiChR++ stimulation (WTbaseline versus KObaseline, P < 0.05; KObaseline versus KOstimulation, P < 0.05) (table S11). (J) Mean social approach velocity with and without inhibitory SwiChR++ stimulation (WTbaseline versus KObaseline, P < 0.05; KObaseline versus KOstimulation, P > 0.05) (table S12). Two separate cohorts were tested and included in the analyses. Data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***, ***P < 0.001, and ****P < 0.0001. Aslihan Selimbeyoglu et al., Sci Transl Med 2017;9:eaah6733 Published by AAAS